ArticleMolecular plant pathology2018
Investigation of the diversity of effector genes in the banana pathogen, Fusarium oxysporum f. sp. cubense, reveals evidence of horizontal gene transfer.
Article in Molecular plant pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 159 citations in OpenAlex.
- Pathogenicity and Virulence ofVirulence · 2026Review
- Genetic and Pathogenic Differentiation ofJournal of fungi (Basel, Switzerland) · 2026Article
- Pathogenicity and Pre-Characterised Putative Effectors ofJournal of fungi (Basel, Switzerland) · 2026Article
- The Multifaceted Menace ofBiology · 2026Review
- Article
- "Secreted in Xylem" Genes (SIX Genes): Relationship to the Aggressiveness ofPlants (Basel, Switzerland) · 2025Article
- Long-Read Draft Genome Sequences of TwoJournal of fungi (Basel, Switzerland) · 2025Article
- Patho-Ecological Distribution and Genetic Diversity ofJournal of fungi (Basel, Switzerland) · 2025Article
- Optimization of a CRISPR-Cas9Frontiers in plant science · 2025Article
- From Natural Hosts to Agricultural Threats: The Evolutionary Journey of Phytopathogenic Fungi.Journal of fungi (Basel, Switzerland) · 2025Review
- Geographical Distribution, Host Range and Genetic Diversity ofJournal of fungi (Basel, Switzerland) · 2024Article
- Histological Dissection of Fusarium-Banana Interaction Using a GFP-Tagged Subtropical Race 4 Strain ofMicroorganisms · 2024Article
- Characterization, Genome Sequencing, and Development of a Rapid PCR Identification Primer forPlants (Basel, Switzerland) · 2024Article
- A ribonuclease T2 protein FocRnt2 contributes to the virulence of Fusarium oxysporum f. sp. cubense tropical race 4.Molecular plant pathology · 2024Article
- Secreted in Xylem (SIX) genes in Fusarium oxysporum f.sp. cubense (Foc) unravels the potential biomarkers for early detection of Fusarium wilt disease.Archives of microbiology · 2024Article
- Molecular characterization of Indian races of Fusarium oxysporum f. sp. lentis (Fol) based on secreted in Xylem (SIX) effector genes and development of a SIX11 gene-based molecular marker for specific detection of Fol.Archives of microbiology · 2024Article
- Characterization of the High-Quality Genome Sequence and Virulence Factors ofJournal of fungi (Basel, Switzerland) · 2024Article
- The structural repertoire ofeLife · 2024Article
- Molecular warfare between pathogenic Fusarium oxysporum R1 and host Crocus sativus L. unraveled by dual transcriptomics.Plant cell reports · 2024Article
- Comparative genomics and transcriptomics reveal differences in effector complement and expression between races ofFrontiers in plant science · 2024Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is hypothesized that the virulence of phytopathogenic fungi is mediated through the secretion of small effector proteins that interfere with the defence responses of the host plant. In Fusarium oxysporum, one family of effectors, the Secreted In Xylem (SIX) genes, has been identified. We sought to characterize the diversity and evolution of the SIX genes in the banana-infecting lineages of F. oxysporum f. sp. cubense (Foc). Whole-genome sequencing data were generated for the 23 genetic lineages of Foc, which were subsequently queried for the 14 known SIX genes (SIX1-SIX14). The sequences of the identified SIX genes were confirmed in a larger collection of Foc isolates. Genealogies were generated for each of the SIX genes identified in Foc to further investigate the evolution of the SIX genes in Foc. Within Foc, variation of the SIX gene profile, including the presence of specific SIX homologues, correlated with the pathogenic race structure of Foc. Furthermore, the topologies of the SIX gene trees were discordant with the topology of an infraspecies phylogeny inferred from EF-1α/RPB1/RPB2 (translation elongation factor-1α/RNA polymerase II subunit I/RNA polymerase II subunit II). A series of topological constraint models provided strong evidence for the horizontal transmission of SIX genes in Foc. The horizontal inheritance of pathogenicity genes in Foc counters previous assumptions that convergent evolution has driven the polyphyletic phylogeny of Foc. This work has significant implications for the management of Foc, including the improvement of diagnostics and breeding programmes.
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