Evidence map›Paper›PMID 28801994›Full record

ArticleMicrocirculation (New York, N.Y. : 1994)2017

Influence of feeding hematocrit and perfusion pressure on hematocrit reduction (Fåhraeus effect) in an artificial microvascular network.

Walter H Reinhart, Nathaniel Z Piety, Sergey S Shevkoplyas

Abstract read
In one paragraph

Article in Microcirculation (New York, N.Y. : 1994), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Establishing a hemoglobin adjustment forMagnetic resonance in medicine · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Blood rheology biomarkers in sickle cell disease.Experimental biology and medicine (Maywood, N.J.) · 2020
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Walter H ReinhartKantonsspital Graubünden, Chur, Switzerland.
Nathaniel Z PietyDepartment of Biomedical Engineering, Cullen College of Engineering, University of Houston, Houston, TX, USA.ORCID 0000-0002-5958-806X
Sergey S ShevkoplyasDepartment of Biomedical Engineering, Cullen College of Engineering, University of Houston, Houston, TX, USA.ORCID 0000-0002-8203-8365

Funding

Eliminating Mediators of Toxicity from Stored BloodR01HL117329 · NHLBI · UNIVERSITY OF HOUSTON · PI SHEVKOPLYAS, SERGEY S · 2012 to 2017
$1.9M
NHLBI NIH HHS R01 HL117329
6 · The paper itself

Abstract

objectiveHct in narrow vessels is reduced due to concentration of fast-flowing RBCs in the center, and of slower flowing plasma along the wall of the vessel, which in combination with plasma skimming at bifurcations leads to the striking heterogeneity of local Hct in branching capillary networks known as the network Fåhraeus effect. We analyzed the influence of feeding Hct and perfusion pressure on the Fåhraeus effect in an AMVN.

methodsRBC suspensions in plasma with Hcts between 20% and 70% were perfused at pressures of 5-60 cm H

resultsChannel Hcts were reduced compared with Hct

conclusionsThe magnitude of the network Fåhraeus effect in an AMVN is inversely related to Hct

Indexed as

Blood PressureModels, CardiovascularCapillariesErythrocytesHematocritHumansartificial microvascular networkFåhraeus effecthematocritmicrovascular perfusionred blood cell

Identifiers

PMID28801994
PMCPMC5673536

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.