Evidence map›Paper›PMID 28801938›Full record

ArticlePharmacotherapy2017

Factors in Variability of Serial Gabapentin Concentrations in Elderly Patients with Epilepsy.

Jeannine M Conway, Lynn E Eberly, Joseph F Collins, Flavia M Macias, R Eugene Ramsay, Ilo E Leppik, Angela K Birnbaum

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jeannine M ConwayExperimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota.
Lynn E EberlyDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Joseph F CollinsVA Medical Center, Perry Point, Maryland.
Flavia M MaciasUniversity of Miami, School of Medicine, Miami, Florida.
R Eugene RamsayUniversity of Miami, School of Medicine, Miami, Florida.
Ilo E LeppikExperimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota.
Angela K BirnbaumExperimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota.
University of Minnesota · USUniversity of Miami · USPerry Point VA Medical Center · US

Funding

TREATMENT OF PATIENTS WITH PSEUDO-SEIZURESP50NS016308 · NINDS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BIRNBAUM, ANGELA K · 1985 to 2006
$8.5M
Clinical Impact of Unstable AED Levels in Elderly Nursing Home Epilepsy PatientsR01AG026390 · NIA · UNIVERSITY OF MINNESOTA · PI BIRNBAUM, ANGELA K · 2007 to 2011
$1.9M
NIA NIH HHS R01 AG026390NINDS NIH HHS P50 NS016308
6 · The paper itself

Abstract

objectivesTo characterize and quantify the variability of serial gabapentin concentrations in elderly patients with epilepsy.

methodsThis study included 83 patients (age ≥ 60 yrs) from an 18-center randomized double-blind double-dummy parallel study from the Veterans Affairs Cooperative 428 Study. All patients were taking 1500 mg/day gabapentin. Within-person coefficient of variation (CV) in gabapentin concentrations, measured weekly to bimonthly for up to 52 weeks, then quarterly, was computed. Impact of patient characteristics on gabapentin concentrations (linear mixed model) and CV (linear regression) were estimated.

resultsA total of 482 gabapentin concentration measurements were available for analysis. Gabapentin concentrations and intrapatient CVs ranged from 0.5 to 22.6 μg/ml (mean 7.9 μg/ml, standard deviation [SD] 4.1 μg/ml) and 2% to 79% (mean 27.9%, SD 15.3%), respectively, across all visits. Intrapatient CV was higher by 7.3% for those with a body mass index of ≥ 30 kg/m

conclusionsSubstantial intrapatient variability in serial gabapentin concentration was noted in elderly patients with epilepsy. Creatinine clearance, time of sampling relative to dose, and obesity were found to be positively associated with variability.

Indexed as

Biological Variation, IndividualAgedAminesAnticonvulsantsBiological AvailabilityCyclohexanecarboxylic AcidsDrug MonitoringEpilepsyGabapentingamma-Aminobutyric AcidHalf-LifeHumansIntestinal AbsorptionMaleMultivariate AnalysisProspective StudiesAminesAnticonvulsantsCyclohexanecarboxylic AcidsGabapentingamma-Aminobutyric Acidantiseizure drugconcentrationelderlyepilepsygabapentinvariability

Identifiers

PMID28801938
PMCPMC9949609
OpenAlexW2742330744

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.