Evidence map›Paper›PMID 28801840›Full record

ReviewCancer metastasis reviews2017

Tobacco-related carcinogenesis in head and neck cancer.

Ashok R Jethwa, Samir S Khariwala

Open access · greenAbstract readHistorical ArticleReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer metastasis reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed, 4 pooled it
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 4 syntheses or guidelines pooled it, 327 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
  5. Article
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  8. Review
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  12. Article
  13. Lifestyle-Based Approaches to Cancer Prevention and Treatment: Diet, Physical Activity, and Integrative Strategies.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Review
  14. Article
  15. Article
  16. Management of Vocal Fold Leukoplakia.World journal of otorhinolaryngology - head and neck surgery · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article

104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ashok R JethwaDepartment of Otolaryngology-Head and Neck Surgery, University of Minnesota, MMC 396, 420 Delaware St SE, Minneapolis, MN, 55455, USA.
Samir S KhariwalaDepartment of Otolaryngology-Head and Neck Surgery, University of Minnesota, MMC 396, 420 Delaware St SE, Minneapolis, MN, 55455, USA. khari001@umn.edu.
University of Minnesota · US

Funding

Tobacco carcinogens as markers of exposure, carcinogenesis and risk in oral canceK23DE023572 · NIDCR · UNIVERSITY OF MINNESOTA · PI KHARIWALA, SAMIR S · 2013 to 2017
$681k
NIDCR NIH HHS K23 DE023572
6 · The paper itself

Abstract

Head and neck cancer (head and neck squamous cell carcinoma (HNSCC)) is a devastating disease. Patients require intensive treatment that is often disfiguring and debilitating. Those who survive are often left with poor speech articulation, difficulties in chewing and swallowing, and cosmetic disfigurement, as well as loss of taste. Furthermore, given that HNSCC survivors are frequently disabled and unable to return to work, the economic and societal costs associated with HNSCC are massive. HNSCC is one of many cancers that are strongly associated with tobacco use. The risk for HNSCC in smokers is approximately ten times higher than that of never smokers, and 70-80% of new HNSCC diagnoses are associated with tobacco and alcohol use. Tobacco products have been used for centuries; however, it is just within the last 60-70 years that we have developed an understanding of their damaging effects. This relatively recent understanding has created a pathway towards educational and regulatory efforts aimed at reducing tobacco use. Understanding the carcinogenic components of tobacco products and how they lead to HNSCC is critical to regulatory and harm reduction measures. To date, nitrosamines and other carcinogenic agents present in tobacco products have been associated with cancer development. The disruption of DNA structure through DNA adduct formation is felt to be a common mutagenic pathway of many carcinogens. Intense work pertaining to tobacco product constituents, tobacco use, and tobacco regulation has resulted in decreased use in some parts of the world. Still, much work remains as tobacco continues to impart significant harm and contribute to HNSCC development worldwide.

Indexed as

AnimalsCarcinogenesisCarcinoma, Squamous CellHead and Neck NeoplasmsHistory, 20th CenturyHistory, 21st CenturyHumansSmokingSquamous Cell Carcinoma of Head and NeckHead and neck squamous cell carcinomaHistory of tobaccoTobacco carcinogenesisTobacco productsTobacco regulation

Identifiers

PMID28801840
PMCPMC5709040
OpenAlexW2742880016

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.