Evidence map›Paper›PMID 28801761›Full record

ArticleInflammation2017

Milonine, a Morphinandienone Alkaloid, Has Anti-Inflammatory and Analgesic Effects by Inhibiting TNF-α and IL-1β Production.

Larissa Rodrigues Silva, Adriano Francisco Alves, Luiz Henrique Agra Cavalcante-Silva, Renan Marinho Braga, Reinaldo Nóbrega de Almeida, José Maria Barbosa-Filho, Márcia Regina Piuvezam

Abstract read
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In one paragraph

Article in Inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Plants (Basel, Switzerland) · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Larissa Rodrigues SilvaLaboratory of Immunopharmacology, Department of Physiology and Pathology, Federal University of Paraíba (UFPB), João Pessoa, PB, 58051-900, Brazil.
Adriano Francisco AlvesDepartment of Pathology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, 31270-901, Brazil.
Luiz Henrique Agra Cavalcante-SilvaLaboratory of Immunopharmacology, Department of Physiology and Pathology, Federal University of Paraíba (UFPB), João Pessoa, PB, 58051-900, Brazil.
Renan Marinho BragaLaboratory of Psychopharmacology, Department of Physiology and Pathology, Federal University of Paraíba (UFPB), João Pessoa, PB, 58051-900, Brazil.
Reinaldo Nóbrega de AlmeidaLaboratory of Psychopharmacology, Department of Physiology and Pathology, Federal University of Paraíba (UFPB), João Pessoa, PB, 58051-900, Brazil.
José Maria Barbosa-FilhoLaboratory de Phytochemistry, Department of Pharmacy, Federal University of Paraíba (UFPB), João Pessoa, PB, 58051-900, Brazil.
Márcia Regina PiuvezamLaboratory of Immunopharmacology, Department of Physiology and Pathology, Federal University of Paraíba (UFPB), João Pessoa, PB, 58051-900, Brazil. mrpiuvezam@ltf.ufpb.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Milonine is a morphinandienone alkaloid from Cissampelos sympodialis Eichl (Menispermaceae), a plant used in Brazil to treat inflammatory disorders. In this study, we evaluated the anti-inflammatory and analgesic activity of milonine (MIL) by using classical experimental models of inflammation and nociception. The results showed that MIL reduced the paw edema formation induced by lipopolysaccharide, prostaglandin E

Indexed as

AnalgesicsAnti-Inflammatory AgentsAnimalsInterleukin-1betaMorphinansNociceptive PainRatsTumor Necrosis Factor-alphaAnalgesicsAnti-Inflammatory AgentsInterleukin-1betamiloninemorphinandienoneMorphinansTumor Necrosis Factor-alphaAcute inflammationAlkaloidAnti-inflammatoryCissampelos sympodialisMilonineNociception

Identifiers

PMID28801761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.