ArticleScientific reports2017
NRF1 and ZSCAN10 bind to the promoter region of the SIX1 gene and their effects body measurements in Qinchuan cattle.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Genomic diversity in Chinese Holstein cattle and genome-wide association study for body conformation traits.BMC genomics · 2025Article
- Bioinformatics analysis and the association of polymorphisms within the caprineAnimal biotechnology · 2023Article
- Genome-Wide Association Studies for Body Conformation Traits in Korean Holstein Population.Animals : an open access journal from MDPI · 2023Article
- Seizure enhances SUMOylation and zinc-finger transcriptional repression in neuronal nuclei.iScience · 2023Article
- Tissue Expression Analysis, Cloning, and Characterization of the 5'-Regulatory Region of the BovineFrontiers in veterinary science · 2022Article
- Effect of Gender to Fat Deposition in Yaks Based on Transcriptomic and Metabolomics Analysis.Frontiers in cell and developmental biology · 2021Article
- Effect of Expressions and SNPs of Candidate Genes on Intramuscular Fat Content in Qinchuan Cattle.Animals : an open access journal from MDPI · 2020Article
- Bioinformatics analysis and genetic polymorphisms in genomic region of the bovine SH2B2 gene and their associations with molecular breeding for body size traits in qinchuan beef cattle.Bioscience reports · 2020Article
- Genetic variants in the TORC2 gene promoter and their association with body measurement and carcass quality traits in Qinchuan cattle.PloS one · 2020Article
- The Molecular Characteristics of theGenes · 2019Article
- Function and Transcriptional Regulation of BovineInternational journal of molecular sciences · 2019Article
- Genetic variants in the SIRT6 transcriptional regulatory region affect gene activity and carcass quality traits in indigenous Chinese beef cattle (Bos taurus).BMC genomics · 2018Article
- Overexpression of theInternational journal of molecular sciences · 2018Article
- Transcriptional Regulation by CpG Sites Methylation in the Core Promoter Region of the Bovine SIX1 Gene: Roles of Histone H4 and E2F2.International journal of molecular sciences · 2018Article
- Characterization of the promoter region of the bovine SIX1 gene: Roles of MyoD, PAX7, CREB and MyoG.Scientific reports · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The SIX1 homeobox gene belongs to the six homeodomain family and is widely thought to play a principal role in mediating of skeletal muscle development. In the present study, we determined that the bovine SIX1 gene was highly expressed in the longissimus thoracis and physiologically immature individuals. DNA sequencing of 428 individual Qinchuan cattle identified nine single nucleotide polymorphisms (SNPs) in the promoter region of the SIX1 gene. Using a series of 5' deletion promoter plasmid luciferase reporter assays and 5'-rapid amplification of cDNA end analysis (RACE), two of these SNPs were found to be located in the proximal minimal promoter region -216/-28 relative to the transcriptional start site (TSS). Correlation analysis showed the combined haplotypes H
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