ArticleScientific reports2017
Extreme anoxia tolerance in crucian carp and goldfish through neofunctionalization of duplicated genes creating a new ethanol-producing pyruvate decarboxylase pathway.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 92 citations in OpenAlex.
- The return of metabolism: biochemistry and physiology of glycolysis.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Mitochondrial responses to anoxia-reoxygenation exposure in crucian carp (Carassius carassius).The Journal of experimental biology · 2026Article
- Pyruvate decarboxylase and its lysine succinylation contribute to the development and metabolite biosynthesis in pathogenic fungusMycology · 2026Article
- Chronic hypoxia induces alternative splicing of transcripts in the goldfish brain.Fish physiology and biochemistry · 2025Article
- Chromosome-level de novo genome assembly of wild, anoxia-tolerant crucian carp, Carassius carassius.Scientific data · 2025Article
- Long-term hypoxia-induced physiological response in turbot Scophthalmus maximus L.Fish physiology and biochemistry · 2024Article
- Maintained mitochondrial integrity without oxygen in the anoxia-tolerant crucian carp.The Journal of experimental biology · 2024Article
- Inherited anoxia tolerance and growth performance can result in enhanced invasiveness in hybrid fish.Biology open · 2024Article
- Phosphoproteomic changes in response to anoxia are tissue-specific in the anoxia-tolerant crucian carp (Frontiers in physiology · 2024Article
- New alternative ingredients and genetic selection are the next game changers in rainbow trout nutrition: a metabolomics appraisal.Scientific reports · 2023Article
- Carbon dioxide and MAPK signalling: towards therapy for inflammation.Cell communication and signaling : CCS · 2023Review
- Chaperone proteins: universal roles in surviving environmental stress.Cell stress & chaperones · 2023Review
- Cardiac Hypoxia Tolerance in Fish: From Functional Responses to Cell Signals.International journal of molecular sciences · 2023Review
- Surviving without oxygen involves major tissue specific changes in the proteome of crucian carp (PeerJ · 2023Article
- Thermostable and OBiology · 2022Article
- New insights into survival strategies to oxygen deprivation in anoxia-tolerant vertebrates.Acta physiologica (Oxford, England) · 2022Review
- Epigenetic and post-transcriptional repression support metabolic suppression in chronically hypoxic goldfish.Scientific reports · 2022Article
- Shaping the cardiac response to hypoxia: NO and its partners in teleost fish.Current research in physiology · 2022Article
- Low Cancer Incidence in Naked Mole-Rats May Be Related to Their Inability to Express the Warburg Effect.Frontiers in physiology · 2022Article
- The goldfish Carassius auratus: an emerging animal model for comparative cardiac research.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Without oxygen, most vertebrates die within minutes as they cannot meet cellular energy demands with anaerobic metabolism. However, fish of the genus Carassius (crucian carp and goldfish) have evolved a specialized metabolic system that allows them to survive prolonged periods without oxygen by producing ethanol as their metabolic end-product. Here we show that this has been made possible by the evolution of a pyruvate decarboxylase, analogous to that in brewer's yeast and the first described in vertebrates, in addition to a specialized alcohol dehydrogenase. Whole-genome duplication events have provided additional gene copies of the pyruvate dehydrogenase multienzyme complex that have evolved into a pyruvate decarboxylase, while other copies retained the essential function of the parent enzymes. We reveal the key molecular substitution in duplicated pyruvate dehydrogenase genes that underpins one of the most extreme hypoxic survival strategies among vertebrates and that is highly deleterious in humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.