ArticleScientific reports2017
Mapping physiological inputs from multiple photoreceptor systems to dopaminergic amacrine cells in the mouse retina.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Retinal Origins of Aberrant Salience in Schizophrenia: The Perceptual Theory.Biological psychiatry global open science · 2026Review
- Altered Retinal Dopamine Homeostasis in Murine Models of Retinitis Pigmentosa.Journal of neurochemistry · 2026Article
- MRI-Based Texture Analysis of the Extraocular Optic Nerve in Idiopathic Parkinson's Disease.Journal of clinical medicine · 2026Article
- Dual-Hit Myopia Mechanism Unveiled by Multi-Omics: Opn1mw Deficiency Primed the Retina for Exaggerated Response to Environmental Defocus.Investigative ophthalmology & visual science · 2026Article
- Divergent molecular and circuit mechanisms underlie light entrainment of retinal and suprachiasmatic nucleus circadian clocks.Cellular and molecular life sciences : CMLS · 2026Article
- A new mouse model for PRPH2 pattern dystrophy exhibits functional compensation prior and subsequent to retinal degeneration.Human molecular genetics · 2024Article
- Dopaminergic amacrine cells express HCN channels in the developing and adult mouse retina.bioRxiv : the preprint server for biology · 2024Article
- Update on central factors in myopia development beyond intraocular mechanisms.Frontiers in neurology · 2024Review
- Seasonal and Annual Change in Physiological Ocular Growth of 7- to 11-Year-Old Norwegian Children.Investigative ophthalmology & visual science · 2023Article
- Dopamine modulates the retinal clock through melanopsin-dependent regulation of cholinergic waves during development.BMC biology · 2023Article
- Association of CX36 Protein Encoding GeneGenes · 2022Article
- Candidate pathways for retina to scleral signaling in refractive eye growth.Experimental eye research · 2022Review
- The Role of GJD2(Cx36) in Refractive Error Development.Investigative ophthalmology & visual science · 2022Review
- Melanopsin modulates refractive development and myopia.Experimental eye research · 2022Article
- Structure and function of the gap junctional network of photoreceptive ganglion cells.Visual neuroscience · 2021Article
- Dopamine-Mediated Circadian and Light/Dark-Adaptive Modulation of Chemical and Electrical Synapses in the Outer Retina.Frontiers in cellular neuroscience · 2021Article
- Thyroid Activating Enzyme, Deiodinase II Is Required for Photoreceptor Function in the Mouse Model of Retinopathy of Prematurity.Investigative ophthalmology & visual science · 2020Article
- Crosstalk: The diversity of melanopsin ganglion cell types has begun to challenge the canonical divide between image-forming and non-image-forming vision.The Journal of comparative neurology · 2020Review
- α-synuclein overexpression in the retina leads to vision impairment and degeneration of dopaminergic amacrine cells.Scientific reports · 2020Article
- Diverse Cell Types, Circuits, and Mechanisms for Color Vision in the Vertebrate Retina.Physiological reviews · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In the vertebrate retina, dopamine is synthesized and released by a specialized type of amacrine cell, the dopaminergic amacrine cell (DAC). DAC activity is stimulated by rods, cones, and melanopsin-expressing intrinsically photosensitive retinal ganglion cells upon illumination. However, the relative contributions of these three photoreceptor systems to the DAC light-induced response are unknown. Here we found that rods excite dark-adapted DACs across a wide range of stimulation intensities, primarily through connexin-36-dependent rod pathways. Similar rod-driven responses were observed in both ventral and dorsal DACs. We further found that in the dorsal retina, M-cones and melanopsin contribute to dark-adapted DAC responses with a similar threshold intensity. In the ventral retina, however, the threshold intensity for M-cone-driven responses was two log units greater than that observed in dorsal DACs, and melanopsin-driven responses were almost undetectable. We also examined the DAC response to prolonged adapting light and found such responses to be mediated by rods under dim lighting conditions, rods/M-cones/melanopsin under intermediate lighting conditions, and cones and melanopsin under bright lighting conditions. Our results elucidate the relative contributions of the three photoreceptor systems to DACs under different lighting conditions, furthering our understanding of the role these cells play in the visual system.
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