Evidence map›Paper›PMID 28801613›Full record

ArticleScientific reports2017

Selective effects of non-thermal atmospheric plasma on triple-negative breast normal and carcinoma cells through different cell signaling pathways.

Yuan Liu, Sheng Tan, Hao Zhang, Xiangjun Kong, Lili Ding, Jie Shen, Yan Lan, Cheng Cheng, Tao Zhu, Weidong Xia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yuan LiuSchool of Life Science, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Sheng TanThe CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Hao ZhangSchool of Life Science, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Xiangjun KongThe CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Lili DingSchool of Life Science, University of Science and Technology of China, Hefei, Anhui, 230027, China.
Jie ShenInstitute of Plasma Physics, Chinese Academy of Sciences, P. O. Box 1126, Hefei, 230031, P. R. China.
Yan LanInstitute of Plasma Physics, Chinese Academy of Sciences, P. O. Box 1126, Hefei, 230031, P. R. China.
Cheng ChengInstitute of Plasma Physics, Chinese Academy of Sciences, P. O. Box 1126, Hefei, 230031, P. R. China. chengcheng@ipp.ac.cn.ORCID 0000-0002-5007-4695
Tao ZhuThe CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, China. zhut@ustc.edu.cn.
Weidong XiaSchool of Life Science, University of Science and Technology of China, Hefei, Anhui, 230027, China. xiawd@ustc.edu.cn.
University of Science and Technology of China · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-thermal atmospheric plasma (NTP) has shown its selective anticancer effects in many types of tumors in vitro and one of the main mechanisms is that the different increase of intracellular ROS in cancer and homologous normal cells. In this study, we report that NTP treatment reduces the proliferation in triple negative breast cancer (TNBC) and normal cell lines. Simultaneously, STAT3 pathway is inhibited by NTP effects. However, it is observed that normal cells MCF10A are more sensitive to ROS toxicity induced by NTP than cancer cells MDA-MB-231. When 5 mM of ROS inhibitor N-acetyl cysteine (NAC) is employed in NTP treatments, the proliferation of normal breast cells MCF10A recovers. Meanwhile, NTP effects remain significant inhibition of MDA-MB-231 cells. Our results further reveal that NTP can induce apoptosis in MDA-MB-231 cells through inhibiting interleukin-6 receptor (IL-6R) pathway. Moreover, the mechanism of NTP anti-cancer selectivity relates to constantly HER2/Akt activation induced by NTP especially in MCF10A cells but not in MDA-MB-231 cells. Therefore, these two different cell signaling pathways induced by NTP treatments in TNBC and homologous normal cells make NTP becoming a potential tool in future therapy.

Indexed as

Signal TransductionApoptosisCarcinomaCell Line, TumorCell ProliferationCells, CulturedHumansPlasma GasesReactive Oxygen SpeciesSTAT3 Transcription FactorTriple Negative Breast NeoplasmsPlasma GasesReactive Oxygen SpeciesSTAT3 Transcription Factor

Identifiers

PMID28801613
PMCPMC5554176
OpenAlexW2742846667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.