ArticleScientific reports2017
Temozolomide arrests glioma growth and normalizes intratumoral extracellular pH.
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Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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0cells of the map it votes in
38citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 53 citations in OpenAlex.
- High-Resolution Imaging of Extracellular pH in Mouse Liver Tumor.NMR in biomedicine · 2026Article
- Tumor microenvironment-specific nanomedicine: from biology-driven to multi-omics-guided precision engineering.Journal of hematology & oncology · 2026Review
- Innovative AC Electrospinning and Characterization of Nanofibers Comprised of Polyvinyl Alcohol and Dacarbazine for Solid State Drug Delivery of Cancer Therapeutic.BioNanoScience · 2026Article
- Overcoming Immune Exclusion in a Murine Model of Cirrhotic Hepatocellular Carcinoma via Cryoablation: Insights from Molecular Extracellular pH Imaging.Research square · 2025Article
- Whole body and hematopoietic cell-specific deletion of G-protein coupled receptor 65 (GPR65) improves insulin sensitivity in diet-induced obese mice.Molecular metabolism · 2025Article
- Role of Amide Proton Transfer Weighted MRI in Predicting MGMTp Methylation Status, p53-Status, Ki-67 Index, IDH-Status, and ATRX Expression in WHO Grade 4 High Grade Glioma.Tomography (Ann Arbor, Mich.) · 2025Article
- Overcoming Resistance to Temozolomide in Glioblastoma: A Scoping Review of Preclinical and Clinical Data.Life (Basel, Switzerland) · 2024Article
- Antiepileptic drug-loaded and multifunctional iron oxide@silica@gelatin nanoparticles for acid-triggered drug delivery.Scientific reports · 2024Article
- Transmembrane pH gradient imaging in rodent glioma models.NMR in biomedicine · 2024Article
- Engineering the glioblastoma microenvironment with bioactive nanoparticles for effective immunotherapy.RSC advances · 2023Review
- Detection of tissue pH with quantitative chemical exchange saturation transfer magnetic resonance imaging.NMR in biomedicine · 2023Review
- Machine learning-based identification of glycosyltransferase-related mRNAs for improving outcomes and the anti-tumor therapeutic response of gliomas.Frontiers in pharmacology · 2023Article
- Preparation of Transdermal Patch Containing Selenium Nanoparticles Loaded with Doxycycline and Evaluation of Skin Wound Healing in a Rat Model.Pharmaceuticals (Basel, Switzerland) · 2022Article
- The Extension of the LeiCNS-PK3.0 Model in Combination with the "Handshake" Approach to Understand Brain Tumor Pathophysiology.Pharmaceutical research · 2022Article
- Evaluation of Temozolomide Treatment for Glioblastoma Using Amide Proton Transfer Imaging and Diffusion MRI.Cancers · 2022Article
- Comparison of metabolic and immunologic responses to transarterial chemoembolization with different chemoembolic regimens in a rabbit VX2 liver tumor model.European radiology · 2022Article
- Quantitative parameter mapping of contrast agent concentration and relaxivity and brain tumor extracellular pH.Scientific reports · 2022Article
- Radiosensitization of Glioma Cells by Temozolomide (TMZ): A Colony Formation Assay.Journal of biomedical physics & engineering · 2022Article
- Extracellular pH Mapping as Therapeutic Readout of Drug Delivery in Glioblastoma.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Impact of Inhibition of the Mitochondrial Pyruvate Carrier on the Tumor Extracellular pH as Measured by CEST-MRI.Cancers · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Jyotsna U RaoMagnetic Resonance Research Center, Yale University, New Haven, CT, USA. jyotsna.u.rao@gmail.com.
Daniel ComanMagnetic Resonance Research Center, Yale University, New Haven, CT, USA. daniel.coman@yale.edu.
John J WalshMagnetic Resonance Research Center, Yale University, New Haven, CT, USA.
Meser M AliDepartment of Neurology, Henry Ford Hospital, Detroit, MI, USA.
Yuegao HuangMagnetic Resonance Research Center, Yale University, New Haven, CT, USA.
Fahmeed HyderMagnetic Resonance Research Center, Yale University, New Haven, CT, USA. fahmeed.hyder@yale.edu.
Yale University · USResonance Research (United States) · USHenry Ford Hospital · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9MNeurophysiologicP30NS052519 · NINDS · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED · 2007 to 2017
$6.7MExtracellular pH mapping as therapeutic readout of drug delivery in glioblastomaR01EB023366 · NIBIB · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED · 2017 to 2020
$2.5MTranslation of smart contrast agents for brain tumor characterization by MRR01CA140102 · NCI · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED · 2010 to 2014
$1.6MTreatment of glioma with nanocombretastatin with MRI monitoringR01CA206190 · NCI · HENRY FORD HEALTH SYSTEM · PI ALI, MESER M. · 2016 to 2019
$1.4MMultivalent PARACEST agents for quantitative molecular imagingR01EB011968 · NIBIB · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED · 2010 to 2013
$1.3MNCI NIH HHS R01 CA140102NCI NIH HHS R01 CA206190NIBIB NIH HHS R01 EB011968NIBIB NIH HHS R01 EB023366NIGMS NIH HHS T32 GM007205NINDS NIH HHS P30 NS052519
Abstract
Gliomas maintain an acidic extracellular pH (pH
Indexed as
AnimalsAntineoplastic Agents, AlkylatingApoptosisBiosensing TechniquesBrain NeoplasmsCell Line, TumorCell ProliferationFemaleGliomaHumansHydrogen-Ion ConcentrationMagnetic Resonance ImagingRats, NudeTemozolomideTumor BurdenXenograft Model Antitumor AssaysAntineoplastic Agents, AlkylatingTemozolomide
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.