ArticleScientific reports2017
Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed.
- Oral Administration of Oxytocin, Like Intranasal Administration, Decreases Top-Down Social Attention.The international journal of neuropsychopharmacology · 2022Trial
- Oxytocin and RAGE signaling at the intersection of social neurodevelopment and inflammation.Journal of translational medicine · 2026Review
- Navigating Central Oxytocin Transport: Known Realms and Uncharted Territories.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- Breast milk oxytocin and s-IgA modulate infant biomarkers and social engagement; The role of maternal anxiety.Comprehensive psychoneuroendocrinology · 2024Article
- Article
- Randomized Double-Blind Crossover Study for Evaluating a Probiotic Mixture on Gastrointestinal and Behavioral Symptoms of Autistic Children.Journal of clinical medicine · 2022Article
- Receptor for advanced glycation end-products and child neglect in mice: A possible link to postpartum depression.Comprehensive psychoneuroendocrinology · 2022Review
- Dual Nature of RAGE in Host Reaction and Nurturing the Mother-Infant Bond.International journal of molecular sciences · 2022Review
- Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside.Frontiers in neuroscience · 2022Review
- Oxytocin and the Neurobiology of Prosocial Behavior.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2021Review
- The oxytocin system and early-life experience-dependent plastic changes.Journal of neuroendocrinology · 2021Review
- Glycation reaction and the role of the receptor for advanced glycation end-products in immunity and social behavior.Glycoconjugate journal · 2021Review
- Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism.BMC neuroscience · 2021Article
- Is Oxytocin "Nature's Medicine"?Pharmacological reviews · 2020Review
- RAGE regulates oxytocin transport into the brain.Communications biology · 2020Review
- One Single Nucleotide Polymorphism of theDiseases (Basel, Switzerland) · 2020Article
- Oxytocin, Vasopressin and Prolactin in New Breastfeeding Mothers: Relationship to Clinical Characteristics and Infant Weight Loss.Journal of human lactation : official journal of International Lactation Consultant Association · 2020Article
- Review
- The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder.International journal of molecular sciences · 2019Review
- Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice.Communications biology · 2019Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasma oxytocin (OT) originates from secretion from the pituitary gland into the circulation and from absorption of OT in mother's milk into the blood via intestinal permeability. However, the molecular mechanism underlying the absorption of OT remains unclear. Here, we report that plasma OT concentrations increased within 10 min after oral delivery in postnatal day 1-7 mice. However, in Receptors for Advanced Glycation End Products (RAGE) knockout mice after postnatal day 3, an identical OT increase was not observed. In adult mice, plasma OT was also increased in a RAGE-dependent manner after oral delivery or direct administration into the intestinal tract. Mass spectrometry evaluated that OT was absorbed intact. RAGE was abundant in the intestinal epithelial cells in both suckling pups and adults. These data highlight that OT is transmitted via a receptor-mediated process with RAGE and suggest that oral OT supplementation may be advantageous in OT drug development.
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Registered trials
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