Evidence map›Paper›PMID 28801529›Full record

ArticleGenetics2017

Silencing of Repetitive DNA Is Controlled by a Member of an Unusual

Eduardo Leyva-Díaz, Nikolaos Stefanakis, Inés Carrera, Lori Glenwinkel, Guoqiang Wang, Monica Driscoll, Oliver Hobert

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 56 citations in OpenAlex.

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  11. Proceedings of the National Academy of Sciences of the United States of America · 2024
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  12. bioRxiv : the preprint server for biology · 2024
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  13. Review
  14. PALS-14 promotes resistance tomicroPublication biology · 2024
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  18. MultiplebioRxiv : the preprint server for biology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Eduardo Leyva-DíazDepartments of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, New York 10027 Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, New York 10027 eld2154@columbia.edu or38@columbia.edu.ORCID 0000-0001-6750-9168
Nikolaos StefanakisDepartments of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, New York 10027 Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, New York 10027.ORCID 0000000010719203142
Inés CarreraDepartments of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, New York 10027 Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, New York 10027.
Lori GlenwinkelDepartments of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, New York 10027 Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, New York 10027.
Guoqiang WangDepartment of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854.
Monica DriscollDepartment of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854.
Oliver HobertDepartments of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, New York 10027 Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, New York 10027 eld2154@columbia.edu or38@columbia.edu.ORCID 0000-0002-7634-2854
Howard Hughes Medical Institute · USColumbia University · USRutgers, The State University of New Jersey · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
CELLULAR AND MOLECULAR FOUNDATIONS OF BIOMEDICAL SCIENCET32GM008798 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI PRYWES, RON M · 2001 to 2018
$6.3M
Mechanisms modulating the maintenance of structural integrity in individual agingR01AG046358 · NIA · RUTGERS, THE STATE UNIV OF N.J. · PI DRISCOLL, MONICA A. · 2013 to 2017
$1.5M
NIA NIH HHS R01 AG046358NIGMS NIH HHS T32 GM008798NIH HHS P40 OD010440
6 · The paper itself

Abstract

Repetitive DNA sequences are subject to gene silencing in various animal species. Under specific circumstances repetitive DNA sequences can escape such silencing. For example, exogenously added, extrachromosomal DNA sequences that are stably inherited in multicopy repetitive arrays in the nematode

Indexed as

Gene SilencingMultigene FamilyRepetitive Sequences, Nucleic AcidAgingAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsNeuronsPhenotypeTransgenesCaenorhabditis elegans ProteinsCaenorhabditis elegansRNA interferencetransgene silencing

Identifiers

PMID28801529
PMCPMC5629321
OpenAlexW2744457913

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.