Evidence map›Paper›PMID 28801508›Full record

ArticleG3 (Bethesda, Md.)2017

Intricate and Cell Type-Specific Populations of Endogenous Circular DNA (eccDNA) in

Massa J Shoura, Idan Gabdank, Loren Hansen, Jason Merker, Jason Gotlib, Stephen D Levene, Andrew Z Fire

Abstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Plasma cell-free extrachromosomal circular DNA is a molecular hallmark of preeclampsia.Computational and structural biotechnology journal · 2025
    Article
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Massa J ShouraDepartment of Pathology, Stanford University School of Medicine, California 94305 massa86@stanford.edu afire@stanford.edu.ORCID 0000-0003-3278-296X
Idan GabdankDepartment of Pathology, Stanford University School of Medicine, California 94305.
Loren HansenDepartment of Pathology, Stanford University School of Medicine, California 94305.
Jason MerkerDepartment of Pathology, Stanford University School of Medicine, California 94305.ORCID 0000-0002-0865-3394
Jason GotlibDepartment of Hematology, Stanford University School of Medicine, California 94305.
Stephen D LeveneDepartment of Bioengineering, University of Texas at Dallas, Richardson, Texas 75080.ORCID 0000-0003-2778-5162
Andrew Z FireDepartment of Pathology, Stanford University School of Medicine, California 94305 massa86@stanford.edu afire@stanford.edu.ORCID 0000-0001-6217-8312

Funding

GENE REGULATION DURING EARLY DEVELOPMENT OF C. ELEGANSR01GM037706 · NIGMS · STANFORD UNIVERSITY · PI FIRE, ANDREW Z. · 1987 to 2018
$11.0M
Single-Molecule DNA TopologyR01GM117595 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI LEVENE, STEPHEN D. · 2015 to 2018
$1.5M
NIGMS NIH HHS R01 GM037706NIGMS NIH HHS R01 GM117595
6 · The paper itself

Abstract

Investigations aimed at defining the 3D configuration of eukaryotic chromosomes have consistently encountered an endogenous population of chromosome-derived circular genomic DNA, referred to as extrachromosomal circular DNA (eccDNA). While the production, distribution, and activities of eccDNAs remain understudied, eccDNA formation from specific regions of the linear genome has profound consequences on the regulatory and coding capabilities for these regions. Here, we define eccDNA distributions in

Indexed as

DNA, CircularAnimalsCaenorhabditis elegansCell LineFibroblastsGranulocytesHumansMaleSpermatocytesDNA, Circular3D genome architectureC. eleganscircular DNAscirculomeeccDNAmucin

Identifiers

PMID28801508
PMCPMC5633380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.