Evidence map›Paper›PMID 28801472›Full record

ReviewClinical cancer research : an official journal of the American Association for Cancer Research2018

Breast Cancer Immunotherapy: Facts and Hopes.

Leisha A Emens

Abstract readReview
In one paragraph

Review in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 531 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
531citing papers in PubMed, 8 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

531 citing papers in PubMed, 8 syntheses or guidelines pooled it, 917 citations in OpenAlex.

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  5. Efficacy and safety of a combination treatment of immune checkpoint inhibitors in metastatic breast cancer: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Pooled it
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471 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Leisha A EmensDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center and Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, Maryland. emensle@jhmi.edu.
Johns Hopkins University · US

Funding

Summer Translational Oncology Program (STOP)R25CA171973 · NCI · JOHNS HOPKINS UNIVERSITY · PI BUNZ, FRED, EMENS, LEISHA A · 2013 to 2017
$340k
NCI NIH HHS R25 CA171973
6 · The paper itself

Abstract

Immunotherapy is revolutionizing the management of multiple solid tumors, and early data have revealed the clinical activity of programmed cell death-1/programmed death ligand-1 (PD-1/PD-L1) antagonists in small numbers of patients with metastatic breast cancer. Clinical activity appears more likely if the tumor is triple negative, PD-L1

Indexed as

ImmunotherapyAnimalsBiomarkers, TumorBreast NeoplasmsClinical Studies as TopicCombined Modality TherapyDrug Evaluation, PreclinicalFemaleHumansImmunomodulationMolecular Targeted TherapyTreatment OutcomeBiomarkers, Tumor

Identifiers

PMID28801472
PMCPMC5796849
OpenAlexW2744067212

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.