ArticleBMJ open2017
SSRI antidepressant use potentiates weight gain in the context of unhealthy lifestyles: results from a 4-year Australian follow-up study.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Pilot trial of a group cognitive behavioural therapy program for comorbid depression and obesity.BMC psychology · 2020Trial
- Adverse event reporting patterns of selective serotonin reuptake inhibitors (SSRIs): disproportionality analysis using the European spontaneous reporting system.European archives of psychiatry and clinical neuroscience · 2026Article
- Disruption of Lipid Profile, Glucose Metabolism, and Leptin Levels following Citalopram Administration and High-Carbohydrate and High-Cholesterol Diet in Mice.Pharmacology · 2025Article
- Article
- Medication-Induced Weight Change Across Common Antidepressant Treatments : A Target Trial Emulation Study.Annals of internal medicine · 2024Observational
- What could be the reasons for not losing weight even after following a weight loss program?Journal of health, population, and nutrition · 2024Review
- Trajectories of antidepressant use and 6-year change in body weight: a prospective population-based cohort study.Frontiers in psychiatry · 2024Article
- Article
- Depression and Anxiety Are Associated With Cardiovascular Health in Young Adults.Journal of the American Heart Association · 2022Article
- Weight-centric treatment of depression and chronic pain.Obesity pillars · 2022Review
- Therapy Management of Metabolic Disorder Comorbidity With Depression.Frontiers in psychology · 2021Review
- Association of first-line antidepressants and incident adverse metabolic effects.Canadian family physician Medecin de famille canadien · 2020Review
- Clozapine: An Updated Overview of Pharmacogenetic Biomarkers, Risks, and Safety-Particularities in the Context of COVID-19.Brain sciences · 2020Review
- Antidepressant utilisation and incidence of weight gain during 10 years' follow-up: population based cohort study.BMJ (Clinical research ed.) · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the association between antidepressant use and weight gain, as well as the interaction with lifestyle factors.
designLongitudinal study. SETTING AND
participantsWe used data from 2334 adults from two stages (4.4 years apart) of the North West Adelaide Health Study, including validated diet and lifestyle questionnaires, measured body weight and linked pharmaceutical prescription data.
main outcome measuresBody weight change.
results188 (8.1%) participants had a mean annual number of 1-2 antidepressant prescriptions, and 212 (9.1%) had over two prescriptions. The mean annual weight gain was 0.12, 0.18 and 0.28 kg in non-users, low (1-2 prescriptions/year) and high (>2 prescriptions/year) antidepressant users, respectively. In multivariable regression models, antidepressant use was positively associated with weight gain: high antidepressant users gained an extra 0.22 (95% CI 0.00 to 0.44) kg per year. This association was mainly due to selective serotonin reuptake inhibitor (SSRI) use. High SSRI users gained 0.48 (95% CI 0.20 to 0.76) kg more than non-users. There was no association between tricyclic or other antidepressant use and weight gain. The association between SSRI use and weight gain was stronger among those with high intake of Western diet, greater sedentary activity, and who smoked.
conclusionsSSRIs use was associated with weight gain in the presence of unhealthy behaviours including Western diet, sedentarism and smoking.
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