Evidence map›Paper›PMID 28801357›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

The Autoimmune Risk Variant

Genita Metzler, Xuezhi Dai, Christopher D Thouvenel, Socheath Khim, Tania Habib, Jane H Buckner, David J Rawlings

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Influence ofFrontiers in immunology · 2021
    Review
  10. Review
  11. Review
  12. Functional Characterization of CD11cJournal of immunology (Baltimore, Md. : 1950) · 2019
    Article
  13. Review
  14. Article
  15. The Contribution of PTPN22 to Rheumatic Disease.Arthritis & rheumatology (Hoboken, N.J.) · 2019
    Review
  16. Article
  17. Anti-Insulin B Cells Are Poised for Antigen Presentation in Type 1 Diabetes.Journal of immunology (Baltimore, Md. : 1950) · 2018
    Article
  18. Genetics of immune-mediated inflammatory diseases.Clinical and experimental immunology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Genita MetzlerCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101.ORCID 0000-0001-8386-0150
Xuezhi DaiCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101.
Christopher D ThouvenelCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101.ORCID 0000-0001-8266-975X
Socheath KhimCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101.
Tania HabibTranslational Research Program, Benaroya Research Institute, Seattle, WA 98101; and.
Jane H BucknerTranslational Research Program, Benaroya Research Institute, Seattle, WA 98101; and.ORCID 0000-0002-9005-1885
David J RawlingsCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA 98101; drawling@u.washington.edu.ORCID 0000-0002-0810-1776
University of Washington · US

Funding

An integrated strategy to define the functional and synergistic impact of T1D causal variantsDP3DK111802 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI RAWLINGS, DAVID J · 2016 to 2016
$4.4M
Defining the functional impact of T1D genes in mouse and man: a unified strategyDP3DK097672 · NIDDK · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI BUCKNER, JANE HOYT · 2012 to 2013
$4.4M
Lentiviral Gene Therapy for Wiskott-Aldrich SyndromeR01AI071163 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI RAWLINGS, DAVID J · 2008 to 2012
$3.5M
Lentiviral Gene Therapy of X-linked AgammaglobulinemiaR01HL075453 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI RAWLINGS, DAVID J · 2004 to 2008
$1.9M
Howard Hughes Medical InstituteNHLBI NIH HHS R01 HL075453NIAID NIH HHS R01 AI071163NIDDK NIH HHS DP3 DK097672NIDDK NIH HHS DP3 DK111802
6 · The paper itself

Abstract

A common genetic variant in the gene encoding the protein tyrosine phosphatase nonreceptor type 22 (

Indexed as

Genetic VariationImmune ToleranceAnimalsAutoimmune DiseasesB-LymphocytesBone MarrowCell Cycle CheckpointsHumansLymphocyte ActivationMiceMutationProtein Tyrosine Phosphatase, Non-Receptor Type 22Receptors, Antigen, B-CellRiskSpleenProtein Tyrosine Phosphatase, Non-Receptor Type 22PTPN22 protein, humanPtpn22 protein, mouseReceptors, Antigen, B-Cell

Identifiers

PMID28801357
PMCPMC6791366
OpenAlexW2743155365

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.