Evidence map›Paper›PMID 28801273›Full record

ReviewNeuroscience letters2018

Building concepts one episode at a time: The hippocampus and concept formation.

Michael L Mack, Bradley C Love, Alison R Preston

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Neuroscience letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05746299 nacompletednot on this mapstarted 2023, after this paper: background citation

The Emergence of Abstract Structure Knowledge Across Learning and Sleep

TypeinterventionalSponsorUniversity of PennsylvaniaRan2023 to 2024Enrolled194ConditionsMemory ConsolidationArmsCongruent vs. Incongruent, Immediate vs. Awake vs. Asleep, Targeted memory reactivation (TMR)
NCT05910762 nacompletednot on this mapstarted 2023, after this paper: background citation

Learning Novel Structure Across Time and Sleep

TypeinterventionalSponsorUniversity of PennsylvaniaRan2023 to 2026Enrolled119ConditionsLearning, Humans, Consolidation, SleepArmsAssociative inference, Category learning, Sleep
3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

  1. Article
  2. Distinct Hippocampal Mechanisms Support Concept Formation and Updating.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Thinking as Analogy-Making: Toward a Neural Process Account of General Intelligence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  10. Article
  11. Article
  12. Navigating space and the developing mind.Frontiers in psychology · 2025
    Review
  13. Article
  14. Dissociable Roles of the Dorsolateral and Ventromedial Prefrontal Cortex in Human Categorization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  15. Article
  16. Event Integration and Temporal Differentiation: How Hierarchical Knowledge Emerges in Hippocampal Subfields through Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  17. Abstract concepts and simulated competition.Psychological research · 2024
    Article
  18. Object Feature Memory Is Distorted by Category Structure.Open mind : discoveries in cognitive science · 2024
    Article
  19. Ingroup sources enhance associative inference.Communications psychology · 2023
    Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael L MackDepartment of Psychology, University of Toronto, Toronto, ON, Canada. Electronic address: mack@psych.utoronto.ca.
Bradley C LoveExperimental Psychology, University College London, London, UK; Alan Turing Institute, London, UK.
Alison R PrestonDepartment of Psychology, The University of Texas at Austin, Austin, TX, USA; Center for Learning and Memory, The University of Texas at Austin, Austin, TX, USA; Department of Neuroscience, The University of Texas at Austin, Austin, TX, USA. Electronic address: apreston@utexas.edu.

Funding

Hippocampal and prefrontal contributions to memory integrationR01MH100121 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI Alison R Preston · 2013 to 2026
$7.3M
ONTOGENESIS OF CATEGORIZATION: LINKING DEVELOPMENT, MECHANISMS, AND BIOLOGYP01HD080679 · NICHD · OHIO STATE UNIVERSITY · PI SLOUTSKY, VLADIMIR M · 2016 to 2020
$5.8M
The mutual influence of attention and learning during knowledge acquisitionF32MH100904 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI MACK, MICHAEL L. · 2013 to 2015
$165k
NICHD NIH HHS P01 HD080679NIMH NIH HHS F32 MH100904NIMH NIH HHS R01 MH100121Wellcome Trust
6 · The paper itself

Abstract

Concepts organize our experiences and allow for meaningful inferences in novel situations. Acquiring new concepts requires extracting regularities across multiple learning experiences, a process formalized in mathematical models of learning. These models posit a computational framework that has increasingly aligned with the expanding repertoire of functions associated with the hippocampus. Here, we propose the Episodes-to-Concepts (EpCon) theoretical model of hippocampal function in concept learning and review evidence for the hippocampal computations that support concept formation including memory integration, attentional biasing, and memory-based prediction error. We focus on recent studies that have directly assessed the hippocampal role in concept learning with an innovative approach that combines computational modeling and sophisticated neuroimaging measures. Collectively, this work suggests that the hippocampus does much more than encode individual episodes; rather, it adaptively transforms initially-encoded episodic memories into organized conceptual knowledge that drives novel behavior.

Indexed as

Memory, EpisodicModels, TheoreticalAttentionConcept FormationHippocampusHumansLearningAttentionComputational modelingConcept learningEpisodic memoryHippocampusPrediction error

Identifiers

PMID28801273
PMCPMC5803467

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.