ArticleVision research2017
Long-wavelength (red) light produces hyperopia in juvenile and adolescent tree shrews.
Article in Vision research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Efficacy of Repeated Low-Level Red Light (RLRL) therapy on myopia outcomes in children: a systematic review and meta-analysis.BMC ophthalmology · 2024Pooled it
- Acute Ocular Effects of Violet and Red Light Exposure in Young Adults.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Potential Inhibitory Effect of LED-Sourced Red Light Therapy on Ocular Growth in Normal and Myopic Chicks.International journal of molecular sciences · 2026Article
- Evaluating the Effect on Emmetropization of the Timing and Spectrum of Breaks From a Myopiagenic Environment.Investigative ophthalmology & visual science · 2026Article
- Ocular Transmission of Red and Violet Light: Insights into Light-Based Myopia Therapies.Translational vision science & technology · 2026Article
- S-Cone Retinal Pathway Dysfunction in Myopia.Investigative ophthalmology & visual science · 2026Article
- Review
- Interaction Between Near Work and Narrowband Light on Choroidal Thickness.Investigative ophthalmology & visual science · 2026Article
- Effect of a longpass filter on myopic defocus-induced changes in axial length and choroid thickness.Frontiers in neuroscience · 2026Article
- IMI: The Role of Light in Refractive Development and Myopia: Evidence from Animal and Human Studies.Investigative ophthalmology & visual science · 2025Review
- Radiometric and safety assessment of a 'low-level red-light' myopia control device.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Development of a Hyperopia Animal Model Using Blue Light in Guinea Pigs.Korean journal of ophthalmology : KJO · 2025Article
- Effects of Blue Light Toward Emmetropization.Cureus · 2025Review
- Low-level red light inhibits human retinal pigment epithelial cell fibrosis via UBE2C in a myopia-simulating hypoxic microenvironment.European journal of medical research · 2025Article
- Childhood Myopia Part II: Treatment Mechanisms, Emerging Options, and Considerations.Investigative ophthalmology & visual science · 2025Review
- How Have Animal Models Increased our Understanding of Human Myopia?Investigative ophthalmology & visual science · 2025Review
- The relationship between contact lens ultraviolet light transmittance and myopia progression: a large-scale retrospective cohort study.Precision clinical medicine · 2024Article
- The Parameters Governing the Anti-Myopia Efficacy of Chromatically Simulated Myopic Defocus in Tree Shrews.Translational vision science & technology · 2024Article
- Red light instruments for myopia exceed safety limits.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2024Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In infant tree shrews, exposure to narrow-band long-wavelength (red) light, that stimulates long-wavelength sensitive cones almost exclusively, slows axial elongation and produces hyperopia. We asked if red light produces hyperopia in juvenile and adolescent animals, ages when plus lenses are ineffective. Animals were raised in fluorescent colony lighting (100-300 lux) until they began 13days of red-light treatment at 11 (n=5, "infant"), 35 (n=5, "juvenile") or 95 (n=5, "adolescent") days of visual experience (DVE). LEDs provided 527-749 lux on the cage floor. To control for the higher red illuminance, a fluorescent control group (n=5) of juvenile (35 DVE) animals was exposed to ∼975 lux. Refractions were measured daily; ocular component dimensions at the start and end of treatment and end of recovery in colony lighting. These groups were compared with normals (n=7). In red light, the refractive state of both juvenile and adolescent animals became significantly (P<0.05) hyperopic: juvenile 3.9±1.0 diopters (D, mean±SEM) vs. normal 0.8±0.1D; adolescent 1.6±0.2D vs. normal 0.4±0.1D. The fluorescent control group refractions (0.6±0.3D) were normal. In red-treated juveniles the vitreous chamber was significantly smaller than normal (P<0.05): juvenile 2.67±0.03mmvs. normal 2.75±0.02mm. The choroid was also significantly thicker: juvenile 77±4μmvs. normal 57±3μm (P<0.05). Although plus lenses do not restrain eye growth in juvenile tree shrews, the red light-induced slowed growth and hyperopia in juvenile and adolescent tree shrews demonstrates that the emmetropization mechanism is still capable of restraining eye growth at these ages.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.