Evidence map›Paper›PMID 28801195›Full record

ArticleSchizophrenia research2018

Avoidance of accelerated aging in schizophrenia?: Clinical and biological characterization of an exceptionally high functioning individual.

Barton W Palmer, Raeanne C Moore, Lisa T Eyler, Luz L Pinto, Elyn R Saks, Dilip V Jeste

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Subjective Overview of Accelerated Aging in Schizophrenia.International journal of environmental research and public health · 2022
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Barton W PalmerDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
Raeanne C MooreDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
Lisa T EylerDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
Luz L PintoDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla, CA, USA.
Elyn R SaksGould School of Law, University of Southern California, Los Angeles, CA, USA.
Dilip V JesteDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA; Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla, CA, USA. Electronic address: djeste@ucsd.edu.
University of California, San Diego · USInstitute on Aging · USUniversity of Southern California · USVA San Diego Healthcare System · US

Funding

FELLOWSHIP IN GERIATRIC MENTAL HEALTHT32MH019934 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Elizabeth W Twamley · 1994 to 2026
$9.5M
Accelerated Inflammaging in SchizophreniaR01MH094151 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EYLER, LISA T · 2012 to 2021
$7.4M
NIMH NIH HHS L30 MH104725NIMH NIH HHS R01 MH094151NIMH NIH HHS T32 MH019934
6 · The paper itself

Abstract

objectiveTo determine the clinical and biological characteristics of an exceptionally high functioning index person (IP) with schizophrenia in her mid-50s, which may represent compensatory mechanisms, and potentially, avoidance of the accelerated aging typically associated with schizophrenia.

methodIP, 11 other women with schizophrenia, and 11 non-psychiatric comparison (NC) women were assessed with standard ratings of psychopathology, neurocognitive function, decisional capacity, and functional brain imaging. IP was also compared to a sample of demographically similar NCs (N=45) and persons with schizophrenia (N=42) on a set of blood-based biomarkers of aging related to metabolic function, oxidative stress, and inflammation.

resultsIP's scores on working memory, and levels of brain activation during an affective face matching task in the left fusiform, right lingual, and left precentral gyri, exceeded NCs. IP was similar to NCs in severity of negative symptoms, most neurocognitive functions, decisional capacity, and brain activation in the left inferior occipital gyrus during a selective stopping task. IP's levels on 11 of 14 metabolic and inflammatory biomarkers of aging were better than NCs and the schizophrenia group.

conclusionAlthough speculative, results suggest a possible model in which superior working memory permits a person to be aware of the potentially psychotic nature of a thought or perception, and adjust response accordingly. Compensatory overactivity of brain regions during affective processing may also reflect heightened meta-awareness in emotional situations. Biomarker levels raise the possibility that IP partially avoided the accelerated biological aging associated with schizophrenia.

Indexed as

Schizophrenic PsychologyAffectAgingBiomarkersBrainFacial RecognitionFemaleHumansMagnetic Resonance ImagingMemory, Short-TermMiddle AgedModels, BiologicalRecognition, PsychologySchizophreniaBiomarkersAgingBiomarkersfMRINeurocognitionPsychosisWorking memory

Identifiers

PMID28801195
PMCPMC6424115
OpenAlexW2744236504

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.