Evidence map›Paper›PMID 28801104›Full record

ArticleBiophysical journal2017

n-Alcohol Length Governs Shift in L

Caitlin E Cornell, Nicola L C McCarthy, Kandice R Levental, Ilya Levental, Nicholas J Brooks, Sarah L Keller

Open access · hybridAbstract read
In one paragraph

Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Yeast cells actively tune their membranes to phase separate at temperatures that scale with growth temperatures.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Caitlin E CornellUniversity of Washington, Department of Chemistry, Seattle, Washington.
Nicola L C McCarthyDepartment of Chemistry, Imperial College London, London, United Kingdom.
Kandice R LeventalDepartment of Integrative Biology and Pharmacology, McGovern Medical School at The University of Texas Medical Center, Houston, Texas.
Ilya LeventalDepartment of Integrative Biology and Pharmacology, McGovern Medical School at The University of Texas Medical Center, Houston, Texas.
Nicholas J BrooksDepartment of Chemistry, Imperial College London, London, United Kingdom.
Sarah L KellerUniversity of Washington, Department of Chemistry, Seattle, Washington. Electronic address: slkeller@chem.washington.edu.
Imperial College London · GBTexas Medical Center · USUniversity of Washington · US

Funding

TRAINING IN MOLECULAR BIOPHYSICST32GM008268 · NIGMS · UNIVERSITY OF WASHINGTON · PI KOLLMAN, JUSTIN M, ZHENG, NING · 1988 to 2023
$8.6M
Lipidomic, biophysical, and functional differentiation of Mesenchymal Stem Cell membranesR01GM114282 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LEVENTAL, ILYA · 2015 to 2019
$1.7M
NIGMS NIH HHS R01 GM114282NIGMS NIH HHS T32 GM008268
6 · The paper itself

Abstract

A persistent challenge in membrane biophysics has been to quantitatively predict how membrane physical properties change upon addition of new amphiphiles (e.g., lipids, alcohols, peptides, or proteins) in order to assess whether the changes are large enough to plausibly result in biological ramifications. Because of their roles as general anesthetics, n-alcohols are perhaps the best-studied amphiphiles of this class. When n-alcohols are added to model and cell membranes, changes in membrane parameters tend to be modest. One striking exception is found in the large decrease in liquid-liquid miscibility transition temperatures (T

Indexed as

Transition TemperatureAlcoholsAnimalsBiomechanical PhenomenaCell Line, TumorCell MembraneCholesterolMicroscopyPhosphatidylcholinesRatsSolutionsUnilamellar LiposomesWater1,2-oleoylphosphatidylcholineAlcoholsCholesterolPhosphatidylcholinesSolutionsUnilamellar LiposomesWater

Identifiers

PMID28801104
PMCPMC5607138
OpenAlexW2742184577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.