Evidence map›Paper›PMID 28800723›Full record

ArticleBMC neuroscience2017

A CLCA regulatory protein present in the chemosensory cilia of olfactory sensory neurons induces a Ca

Casilda V Mura, Ricardo Delgado, María Graciela Delgado, Diego Restrepo, Juan Bacigalupo

Open access · goldAbstract read
In one paragraph

Article in BMC neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Calcium-Activated ClInternational journal of molecular sciences · 2018
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Casilda V MuraDepartment of Biology, Faculty of Sciences, University of Chile, Las Palmeras 3425, Ñuñoa, 7800024, Santiago, Chile.
Ricardo DelgadoDepartment of Biology, Faculty of Sciences, University of Chile, Las Palmeras 3425, Ñuñoa, 7800024, Santiago, Chile.
María Graciela DelgadoDepartment of Biology, Faculty of Sciences, University of Chile, Las Palmeras 3425, Ñuñoa, 7800024, Santiago, Chile.
Diego RestrepoDepartment of Cell and Developmental Biology, Neuroscience Program and Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Juan BacigalupoDepartment of Biology, Faculty of Sciences, University of Chile, Las Palmeras 3425, Ñuñoa, 7800024, Santiago, Chile. bacigalu@uchile.cl.ORCID 0000-0003-2688-6068
University of Chile · CLRocky Mountain MS Center · US

Funding

Olfactory receptors for semiochemical detection in the main olfactory epitheliumR01DC014253 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI RESTREPO, DIEGO · 2015 to 2019
$2.4M
NIDCD NIH HHS R01 DC014253
6 · The paper itself

Abstract

backgroundCLCA is a family of metalloproteases that regulate Ca

resultsWe cloned and expressed CLCA4L from rat olfactory epithelium in HEK293 cells. In the transfected HEK293 cells we measured a Cl

conclusionThese findings suggests that a CLCA isoform, namely CLCA4L, expressed in OSN cilia, might have a regulatory function over the ANO2-dependent Ca

Indexed as

Amino Acid SequenceAnimalsAnoctaminsCalciumChloride ChannelsChloridesCiliaCloning, MolecularHEK293 CellsHumansIonsMaleMembrane PotentialsOlfactory Receptor NeuronsProtein IsoformsRats, Sprague-DawleyANO2 protein, humanAnoctaminsCalciumChloride ChannelsChloridesCLCA4L protein, ratIonsProtein IsoformsRNA, MessengerAnoctamin channelsCa2+-activated Cl− currentCLCAOlfactory cilia

Identifiers

PMID28800723
PMCPMC5553735
OpenAlexW2744259736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.