Evidence map›Paper›PMID 28800620›Full record

ArticlePloS one2017

Experimental study of ASCs combined with POC-PLA patch for the reconstruction of full-thickness chest wall defects.

Yuanzheng Zhang, Shuo Fang, Jiezhi Dai, Lei Zhu, Hao Fan, Weiya Tang, Yongjie Fan, Haiying Dai, Peipei Zhang, Ying Wang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Yuanzheng ZhangDepartment of Plastic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, PR China.
Shuo FangDepartment of Plastic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, PR China.
Jiezhi DaiDepartment of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, PR China.
Lei ZhuState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, PR China.
Hao FanDepartment of Plastic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, PR China.
Weiya TangDepartment of Plastic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, PR China.
Yongjie FanDepartment of Plastic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, PR China.
Haiying DaiDepartment of Plastic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, PR China.
Peipei ZhangDepartment of Plastic Surgery, the 455th hospital of Chinese People's Liberation Army, Shanghai, PR China.
Ying WangDepartment of Plastic Surgery, the 455th hospital of Chinese People's Liberation Army, Shanghai, PR China.
Xin XingDepartment of Plastic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, PR China.
Chao YangDepartment of Plastic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, PR China.ORCID http://orcid.org/0000-0002-4004-488X
Second Military Medical University · CNChinese People 's Liberation Army No.455 Hospital · CNDonghua University · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To explore the repairing effect of combination of adipose stem cells (ASCs) and composite scaffolds on CWR, the electrospun Poly 1, 8-octanediol-co-citric acid (POC)-poly-L-lactide acid (PLA) composite scaffolds were prepared, followed by in vitro and in vivo biocompatibility evaluation of the scaffolds. Afterwards, ASCs were seeded on POC-PLA to construct the POC-PLA-ASCs scaffolds, and the POC-PLA, POC-PLA-ASCs, and traditional materials expanded polytetrafluoroethylene (ePTFE) were adopt for CWR in New Zealand white (NZW) rabbit models. As results, the POC-PLA-ASCs patches possessed good biocompatibility as the high proliferation ability of cells surrounding the patches. Rabbits in POC-PLA-ASCs groups showed better pulmonary function, less pleural adhesion, higher degradation rate and more neovascularization when compared with that in other two groups. The results of western blot indicated that POC-PLA-ASCs patches accelerated the expression of VEGF and Collagen I in rabbit models. From the above, our present study demonstrated that POC-PLA material was applied for CWR successfully, and ASCs seeded on the sheets could improve the pleural adhesions and promote the reparation of chest wall defects.

Indexed as

Tissue ScaffoldsAdipose TissueAnimalsBiomarkersCell- and Tissue-Based TherapyCells, CulturedCitratesCollagen Type ICongenital AbnormalitiesFemaleGene ExpressionMaleNeovascularization, PhysiologicPolyestersPolymersPolytetrafluoroethyleneBiomarkersCitratesCollagen Type Ipoly(1,8-octanediol citrate)Polyesterspoly(lactide)PolymersPolytetrafluoroethyleneVascular Endothelial Growth Factor A

Identifiers

PMID28800620
PMCPMC5553644
OpenAlexW2744852221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.