Evidence map›Paper›PMID 28800366›Full record

ArticleJournal of extracellular vesicles2017

Proceedings of the ISEV symposium on "HIV, NeuroAIDS, drug abuse & EVs".

Guoku Hu, Kenneth W Witwer, Vincent C Bond, Norman Haughey, Fatah Kashanchi, Lynn Pulliam, Shilpa Buch

Abstract read
In one paragraph

Article in Journal of extracellular vesicles, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Extracellular vesicle-mediated delivery of anti-miR-106b inhibits morphine-induced primary ciliogenesis in the brain.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Article
  3. Strategies for the use of Extracellular Vesicles for the Delivery of Therapeutics.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guoku HuDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
Kenneth W WitwerDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Vincent C BondDepartment of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA, USA.
Norman HaugheyDepartment of Neurology, the Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Fatah KashanchiLaboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA.
Lynn PulliamDepartments of Laboratory Medicine and Medicine, University of California, San Francisco, San Francisco, CA, USA.
Shilpa BuchDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.

Funding

Therapeutic CoreP30MH075673 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Leah Helane Rubin, Barbara Stauch Slusher · 2006 to 2026
$33.2M
Research Desogn and Biostatistics CoreU54MD007588 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI MAYBERRY, ROBERT M · 2012 to 2018
$24.8M
TRANSPLANTATION OF EXOSOMES FROM HYPOXIA-PRECONDITIONED ADIPOSE-DERIVED STEM CELLS PROMOTES ANGIOGENESIS IN ISCHEMIC HEARTG12MD007602 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI BOND, VINCENT C · 2012 to 2017
$18.4M
TISSUE CULTURE MODEL FOR RETINITIS PIGMENTOSA--A MOLECULAR APPROACHR25GM058268 · NIGMS · MOREHOUSE SCHOOL OF MEDICINE · PI HARRIS-HOOKER, SANDRA, STILES, JONATHAN K. · 1998 to 2023
$16.5M
Renewal Application for Clinical Research Education and Career Development (CRECDR25MD007589 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI PRISCILLA E PEMU, Alexander Quarshie · 2012 to 2026
$5.4M
HIV1 INHIBITION USING TAT PEPTIDE DERIVATIVESR01AI043894 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI KASHANCHI, FATAH · 1999 to 2015
$4.4M
Hepatitis C Drives Neuropathogenesis in HIV/HCV Coinfection PatientsR01MH085538 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI PULLIAM, LYNN · 2009 to 2017
$3.6M
Nebraska Center for VirologyP30GM103509 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI WOOD, CHARLES · 2012 to 2014
$3.3M
Plasma miRNA Biomarkers of HIV/SIV CNS DiseaseR01NS076357 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E · 2012 to 2016
$2.7M
HIV Tat & Morphine induce mircroglial migration & activation via release of miR-9 & 138R01DA040397 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BUCH, SHILPA J., FOX, HOWARD S · 2015 to 2019
$2.5M
Extracellular Vesicle-Mediated Immunomodulation in HIV Infection and Nicotine AbuseR01DA040385 · NIDA · JOHNS HOPKINS UNIVERSITY · PI WITWER, KENNETH W · 2015 to 2019
$2.3M
HIV-1 mediated synaptodendritic injury and microglial activation: Role of extracellular vesicle miRNAsR01MH112848 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BUCH, SHILPA J., HU, GUOKU · 2017 to 2021
$2.1M
NCATS NIH HHS R13 TR001278NHLBI NIH HHS R21 HL129853NIAID NIH HHS R01 AI043894NIAID NIH HHS R21 AI074410NIAID NIH HHS R21 AI078859NIAID NIH HHS R21 AI095150NIDA NIH HHS R01 DA040385NIDA NIH HHS R01 DA040390NIDA NIH HHS R01 DA040397NIDA NIH HHS R01 DA043138NIGMS NIH HHS P30 GM103509NIGMS NIH HHS R25 GM058268NIMHD NIH HHS G12 MD007602NIMHD NIH HHS R25 MD007589NIMHD NIH HHS U54 MD007588NIMH NIH HHS P30 MH075673NIMH NIH HHS R01 MH085538NIMH NIH HHS R01 MH112848NINDS NIH HHS F31 NS086453NINDS NIH HHS R01 NS076357
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are globular, membrane bound nanovesicles (30-100 nm range) that are shed both during normal cellular functioning and under pathological conditions by most cell types. In recent years, there has been significant interest in the study of these vesicles as conduits for the delivery of information between cells from both analogous and disparate tissues. Their ability to carry specialised cargo including signalling mediators, proteins, messenger RNA and miRNAs characterises these vesicles as primary facilitators of cell-to-cell communication and regulation. EVs have also been demonstrated to play important roles in the field of cancer biology and metastasis. However, significant knowledge gaps exist in the role these vesicles play in the context of HIV infection and drug abuse. To foster discussion in this area a satellite symposium on "HIV, NeuroAIDS, Drug Abuse & EVs", was held in conjunction with the annual meeting of the International Society for Extracellular Vesicles (ISEV) in Bethesda, in April 2015. Experts in HIV and drug abuse fields were invited to share their findings on the role of EVs in HIV-1 infection and drug addiction. Additional discussion included current areas of research in EV biology in HIV infection and drug abuse.

Indexed as

drug abuseExtracellular vesicles (EVs)human immunodeficiency virus (HIV)NeuroAIDS

Identifiers

PMID28800366
PMCPMC5373676

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.