Evidence map›Paper›PMID 28800328›Full record

Trial reportJournal of Alzheimer's disease : JAD2017

Effects of Exercise on Cognitive Function in Older People with Dementia: A Randomized Controlled Trial.

Annika Toots, Håkan Littbrand, Gustaf Boström, Carl Hörnsten, Henrik Holmberg, Lillemor Lundin-Olsson, Nina Lindelöf, Peter Nordström, Yngve Gustafson, Erik Rosendahl

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of Alzheimer's disease : JAD, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05877196 (Precision Medicine in Alzheimer's Disease), which is not on this map. Cited by 50 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 17 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05877196 narecruitingnot on this mapstarted 2023, after this paper: background citation

Precision Medicine in Alzheimer's Disease: A SMART Trial of Adaptive Exercises and Their Mechanisms of Action Using AT(N) Biomarkers to Optimize Aerobic-Fitness Responses (The FIT-AD SMART Trial)

TypeinterventionalSponsorArizona State UniversityRan2023 to 2028Enrolled216ConditionsMild Cognitive Impairment, Alzheimer Disease, Cognitive Impairment, Cognitive DeclineArmsModerate Intensity Continuous Training (MICT), Chair-based Stretch, High-Intensity Interval Training (HIIT), Combined Aerobic Resistance Exercise (CARE)
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 17 syntheses or guidelines pooled it.

  1. Pooled it
  2. The effect of exercise on the improvement of verbal fluency, spatial working memory, and the three major executive functions in elderly alzheimer's patients: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  4. Interventions for preventing falls in older people in care facilities.The Cochrane database of systematic reviews · 2025
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  11. Physical and Motor Fitness Tests for Older Adults Living in Nursing Homes: A Systematic Review.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Annika TootsDepartment of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.
Håkan LittbrandDepartment of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.
Gustaf BoströmDepartment of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.
Carl HörnstenDepartment of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.
Henrik HolmbergDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Lillemor Lundin-OlssonDepartment of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.
Nina LindelöfDepartment of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.
Peter NordströmDepartment of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.
Yngve GustafsonDepartment of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.
Erik RosendahlDepartment of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough physical exercise has been suggested to influence cognitive function, previous exercise studies show inconsistent results in people with dementia.

objectivesTo investigate effects of exercise on cognitive function in people with dementia.

methodThe Umeå Dementia and Exercise (UMDEX) study, a cluster-randomized controlled trial, was set in 16 nursing homes in Umeå, Sweden. One hundred-and-forty-one women and 45 men with dementia; mean age of 85 y and mean Mini-Mental State Examination (MMSE) score of 15, were randomized to a High-Intensity Functional Exercise program or a seated attention control activity. Blinded assessors measured global cognitive function using the MMSE and the Alzheimer's disease Assessment Scale - Cognitive subscale (ADAS-Cog), and executive function using Verbal fluency (VF) at baseline and 4 months (directly after intervention completion), and MMSE and VF at 7 months.

resultsLinear mixed models showed no between-group effects in mean difference from baseline (95% confidence intervals, CI) at 4 months in MMSE (-0.27; 95% CI -1.4 to 0.87, p = 0.644), ADAS-Cog (-1.04, 95% CI -4 to 1.92, p = 0.491), or VF (-0.53, 95% CI -1.42 to 0.35, p = 0.241) or at 7 months in MMSE (-1.15, 95% CI -2.32 to 0.03, p = 0.056) or VF (-0.18, 95% CI -1.09 to 0.74, p = 0.707).

conclusionA 4-month, high-intensity functional exercise program had no superior effects on global cognition or executive function in people with dementia living in nursing homes when compared with an attention control activity.

Indexed as

AgedAged, 80 and overCognition DisordersDementiaExerciseExercise TherapyFemaleHumansMaleMental Status ScheduleNeuropsychological TestsOutcome Assessment, Health CareCognitiondementiaexerciseresidential facilities

Identifiers

PMID28800328
PMCPMC5611799

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.