Evidence map›Paper›PMID 28799918›Full record

SynthesisEnvironmental health perspectives2017

Developmental PBDE Exposure and IQ/ADHD in Childhood: A Systematic Review and Meta-analysis.

Juleen Lam, Bruce P Lanphear, David Bellinger, Daniel A Axelrad, Jennifer McPartland, Patrice Sutton, Lisette Davidson, Natalyn Daniels, Saunak Sen, Tracey J Woodruff

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Environmental health perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed, 21 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 21 syntheses or guidelines pooled it.

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  20. Effects of Polybrominated Diphenyl Ethers on Child Cognitive, Behavioral, and Motor Development.International journal of environmental research and public health · 2018
    Pooled it

57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Juleen LamProgram on Reproductive Health and the Environment, University of California , San Francisco, San Francisco, California, USA.
Bruce P LanphearSimon Fraser University , Vancouver, British Columbia, Canada.
David BellingerHarvard School of Public Health, Harvard University , Boston, Massachusetts, USA.
Daniel A AxelradOffice of Policy, U.S. Environmental Protection Agency , Washington, District of Columbia, USA.
Jennifer McPartlandEnvironmental Defense Fund , Washington, District of Columbia, USA.
Patrice SuttonProgram on Reproductive Health and the Environment, University of California , San Francisco, San Francisco, California, USA.
Lisette DavidsonDepartment of Obstetrics and Gynecology, Kaiser Permanente , Oakland, California, USA.
Natalyn DanielsProgram on Reproductive Health and the Environment, University of California , San Francisco, San Francisco, California, USA.
Saunak SenUniversity of Tennessee Health Science Center , Memphis, Tennessee, USA.
Tracey J WoodruffProgram on Reproductive Health and the Environment, University of California , San Francisco, San Francisco, California, USA.

Funding

Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2M
The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's CenterP01ES022841 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, TRACEY J. · 2013 to 2018
$3.9M
NICHD NIH HHS U54 HD090255NIEHS NIH HHS P01 ES022841
6 · The paper itself

Abstract

backgroundIn the United States, one in six children are affected by neurodevelopmental disorders, and polybrominated diphenyl ethers (PBDEs) in flame-retardant chemicals are measured ubiquitously in children.

objectiveWe conducted a systematic a systematic review regarding developmental exposure to PBDEs and intelligence or Attention Deficit/Hyperactivity Disorder (ADHD) and attention-related behavioral conditions in humans.

methodsWe searched articles published up to 26 September 2016, and included original studies that quantified exposures to PBDEs incurred any time in proximity to conception or during

resultsFifteen studies met the inclusion criteria; 10 studies met the criteria for intelligence and nine for attention-related problems. We rated studies generally with "low" to "probably low" risk of bias and rated the overall body of evidence as "moderate" quality with "sufficient" evidence for an association between Intelligence Quotient (IQ) and PBDEs. Our meta-analysis of four studies estimated a 10-fold increase (in other words, times 10) in PBDE exposure associated with a decrement of 3.70 IQ points (95% confidence interval: 0.83, 6.56). We concluded the body of evidence was of "moderate" quality for ADHD with "limited" evidence for an association with PBDEs, based on the heterogeneity of association estimates reported by a small number of studies and the fact that chance, bias, and confounding could not be ruled out with reasonable confidence.

conclusionWe concluded there was sufficient evidence supporting an association between developmental PBDE exposure and reduced IQ. Preventing developmental exposure to PBDEs could help prevent loss of human intelligence. https://doi.org/10.1289/EHP1632.

Indexed as

Environmental ExposureAttentionAttention Deficit Disorder with HyperactivityChildChild DevelopmentChild, PreschoolEnvironmental PollutantsFemaleFlame RetardantsHalogenated Diphenyl EthersHumansInfantInfant, NewbornIntelligenceMaternal ExposurePregnancyEnvironmental PollutantsFlame RetardantsHalogenated Diphenyl Ethers

Identifiers

PMID28799918
PMCPMC5783655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.