ArticleeLife2017
Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Deletion of neurosecretory proteins GL and GM drives dual anti-obesity effects via appetite suppression and enhanced energy expenditure.Communications biology · 2026Article
- Weight Gain With Advancing Age Is Controlled by the Muscarinic Acetylcholine Receptor M4 in Male Mice.Endocrinology · 2025Article
- Recent Research on Mechanisms of Feeding Regulation in Chicks.The journal of poultry science · 2024Review
- Neurosecretory Protein GM-Expressing Neurons Participate in Lipid Storage and Inflammation in Newly Developed Cre Driver Male Mice.Biomedicines · 2023Article
- Nanomolar range of FAM237B can activate receptor GPR83.Amino acids · 2023Article
- Profiling mouse brown and white adipocytes to identify metabolically relevant small ORFs and functional microproteins.Cell metabolism · 2023Article
- Neurosecretory Protein GL Promotes Normotopic Fat Accumulation in Male ICR Mice.International journal of molecular sciences · 2022Article
- Immunohistochemical Analysis of Neurotransmitters in Neurosecretory Protein GL-Producing Neurons of the Mouse Hypothalamus.Biomedicines · 2022Article
- Neurosecretory Protein GL Accelerates Liver Steatosis in Mice Fed Medium-Fat/Medium-Fructose Diet.International journal of molecular sciences · 2022Article
- Effect of Stressors on the mRNA Expressions of Neurosecretory Protein GL and Neurosecretory Protein GM in Chicks.Frontiers in physiology · 2022Article
- Gut microbiota-a positive contributor in the process of intermittent fasting-mediated obesity control.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Review
- Overexpression of the Gene Encoding Neurosecretory Protein GL Precursor Prevents Excessive Fat Accumulation in the Adipose Tissue of Mice Fed a Long-Term High-Fat Diet.Molecules (Basel, Switzerland) · 2021Article
- Article
- Effects of Overexpression of Neurosecretory Protein GL-Precursor Gene on Glucose Homeostasis and Insulin Sensitivity in Mice.International journal of molecular sciences · 2021Article
- Effects of Irregular Feeding on the Daily Fluctuations in mRNA Expression of the Neurosecretory Protein GL and Neurosecretory Protein GM Genes in the Mouse Hypothalamus.International journal of molecular sciences · 2021Article
- A Novel Hypothalamic Factor, Neurosecretory Protein GM, Causes Fat Deposition in Chicks.Frontiers in physiology · 2021Article
- Neurosecretory Protein GL Induces Fat Accumulation in Chicks.Frontiers in endocrinology · 2019Article
- Regulation and Metabolic Significance ofNutrients · 2018Review
- A global comparison of the microbiome compositions of three gut locations in commercial pigs with extreme feed conversion ratios.Scientific reports · 2018Article
- Localization and function of neurosecretory protein GM, a novel small secretory protein, in the chicken hypothalamus.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanisms underlying the central regulation of food intake and fat accumulation are not fully understood. We found that neurosecretory protein GL (NPGL), a newly-identified neuropeptide, increased food intake and white adipose tissue (WAT) in rats. NPGL-precursor gene overexpression in the hypothalamus caused increases in food intake, WAT, body mass, and circulating insulin when fed a high calorie diet. Intracerebroventricular administration of NPGL induced de novo lipogenesis in WAT, increased insulin, and it selectively induced carbohydrate intake. Neutralizing antibody administration decreased the size of lipid droplets in WAT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.