Evidence map›Paper›PMID 28799793›Full record

ReviewEpigenomics2017

Towards quantitative analysis of gene regulation by enhancers.

Ekaterina V Nizovtseva, Stefjord Todolli, Wilma K Olson, Vasily M Studitsky

Open access · greenAbstract readReview
In one paragraph

Review in Epigenomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. A Feedback Loop Between Fatty Acid Metabolism and Epigenetics in Clear Cell Renal Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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  13. Review
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  15. Dysregulated Transcriptional Control in Prostate Cancer.International journal of molecular sciences · 2019
    Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Ekaterina V NizovtsevaCancer Epigenetics Program, Fox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19422, USA.
Stefjord TodolliDepartment of Chemistry & Chemical Biology, Center for Quantitative Biology, Rutgers, the State University of New Jersey, 610 Taylor Rd., Piscataway, NJ 08854, USA.
Wilma K OlsonDepartment of Chemistry & Chemical Biology, Center for Quantitative Biology, Rutgers, the State University of New Jersey, 610 Taylor Rd., Piscataway, NJ 08854, USA.
Vasily M StuditskyCancer Epigenetics Program, Fox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19422, USA.
Rutgers, The State University of New Jersey · USFox Chase Cancer Center · USLomonosov Moscow State University · RU

Funding

THEORETICFAL ASPECTS OF DNA SUPERCOILINGR01GM034809 · NIGMS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI OLSON, WILMA K · 1985 to 2019
$4.6M
Mechanism of yFACT Action during Chromatin TranscriptionR01GM119398 · NIGMS · RESEARCH INST OF FOX CHASE CAN CTR · PI STILLMAN, DAVID J, STUDITSKY, VASILY M · 2017 to 2020
$1.3M
NIGMS NIH HHS R01 GM034809NIGMS NIH HHS R01 GM119398
6 · The paper itself

Abstract

Enhancers are regulatory DNA sequences that can activate transcription over large distances. Recent studies have revealed the widespread role of distant activation in eukaryotic gene regulation and in the development of various human diseases, including cancer. Here we review recent progress in the field, focusing on new experimental and computational approaches that quantify the role of chromatin structure and dynamics during enhancer-promoter interactions in vitro and in vivo.

Indexed as

Enhancer Elements, GeneticEpigenesis, GeneticAnimalsChromatinGenomicsHumansChromatinactivationdistant actionenhancersmechanismspromoters

Identifiers

PMID28799793
PMCPMC5585842
OpenAlexW2745126693

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.