Evidence map›Paper›PMID 28799551›Full record

ReviewNature reviews. Neurology2017

The tension between early diagnosis and misdiagnosis of multiple sclerosis.

Andrew J Solomon, John R Corboy

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03586986 (Risk Factors in Early Multiple Sclerosis), which is not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03586986 unknown statusnot on this mapstarted 2018, after this paper: background citation

Risk Factors in Early Multiple Sclerosis

TypeobservationalSponsorUniversity of Colorado, DenverRan2018 to 2024Enrolled300ConditionsMultiple Sclerosis, Magnetic Resonance Imaging, Biomarkers, Clinically Isolated SyndromeArmsBrain MRI
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Incorporation of the central vein sign into the McDonald criteria.Multiple sclerosis and related disorders · 2025
    Article
  6. Article
  7. Misdiagnosis of Multiple Sclerosis: Past, Present, and Future.Current neurology and neuroscience reports · 2024
    Review
  8. Article
  9. Article
  10. A Blood Test for the Diagnosis of Multiple Sclerosis.International journal of molecular sciences · 2024
    Article
  11. Article
  12. Article
  13. Observational
  14. Paramagnetic rims are a promising diagnostic imaging biomarker in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022
    Article
  15. An Update on Diagnostic Laboratory Biomarkers for Multiple Sclerosis.Current neurology and neuroscience reports · 2022
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Diagnosis of multiple sclerosis using multifocal ERG data feature fusion.An international journal on information fusion · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Andrew J SolomonUniversity of Vermont College of Medicine, 1 South Prospect Street, Burlington, Vermont 05401, USA.
John R CorboyUniversity of Colorado School of Medicine, 12631 East 17th Avenue, B185 Aurora, Colorado 80045, USA, and at Denver Veterans Affairs Medical Center, 1055 Clermont Street, Denver, Colorado 80220, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Diagnostic ErrorsEarly DiagnosisEarly Medical InterventionHumansImmunologic FactorsMultiple SclerosisImmunologic Factors

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.