ArticleInternational journal of immunopathology and pharmacology2017
Structural evaluation of the peritubular sheath of rat's testes after administration of ribavirin: A possible impact on the testicular function.
Article in International journal of immunopathology and pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Effect of COVID-19 on Male Reproductive System - A Systematic Review.Frontiers in endocrinology · 2021Pooled it
- A porcine model of chronic hepatitis E virus (HEV) infection identifies male reproductive glands as sites of viral persistence.Virulence · 2026Article
- Ferroptotic Pathway Activation in Spermatogonia: A Novel Mechanism of Busulfan-Induced Testicular Injury.Biology · 2025Article
- Review
- Growing concerns on male reproductive health amidst COVID-19 pandemic.Journal of family medicine and primary care · 2022Review
- Is there impact of the SARS-CoV-2 pandemic on steroidogenesis and fertility?Physiological research · 2021Review
- COVID-19 and male reproductive system: pathogenic features and possible mechanisms.Journal of molecular histology · 2021Review
- Testicular Atrophy and Hypothalamic Pathology in COVID-19: Possibility of the Incidence of Male Infertility and HPG Axis Abnormalities.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Possible Male Reproduction Complications after Coronavirus Pandemic.Cell journal · 2021Review
- COVID-19 Pandemic and Male Fertility: Clinical Manifestations and Pathogenic Mechanisms.Biochemistry. Biokhimiia · 2021Review
- Viral pathogenesis of SARS-CoV-2 infection and male reproductive health.Open biology · 2021Review
- SARS-CoV-2 and Male Infertility: Possible Multifaceted Pathology.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Potential risks of SARS-CoV-2 infection on reproductive health.Reproductive biomedicine online · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effects of ribavirin on the structure of peritubular sheath (PS) of seminiferous tubules and on testicular functions were studied. We found that ribavirin at a dose of 4 mg/kg/day for 4 weeks produced a significant reduction in testosterone level (6.3 ± 0.2; P < 0.001) and in spermatogenic score count (3.8 ± 0.2; P < 0.001) compared to control values. The thickness of PS (17.8 ± 1.13) and tubular lumen perimeter (1024.7 ± 67) was significantly increased compared to controls (10.7 ± 0.70; P < 0.001 and 808 ± 25; P = 0.004, respectively). The length of germinal epithelium (411.8 ± 39) and tubular external diameters (1661.8 ± 115) was significantly reduced compared to control values (708.4 ± 40; P < 0.001 and 2358.8 ± 169; P < 0.001, respectively). The basement membranes (BMs) were thickened with great deposition of collagen. Myoid cells showed altered structure and extracellular matrix revealed disorganization by excessive collagen I and IV accumulation. Testicular damage was established histologically. Evidence of apoptosis was detected in germ cells. There was a significant increase in integrated density of Casp-3 expression (38,121,743 ± 1,763,420; P < 0.001) in seminiferous tubules compared to control (24,788,409 ± 1,900,140). It is concluded that ribavirin can cause alterations of the testicular function and structure with increased apoptosis in the tissues after 4 weeks of administration. The damaging effect could be persuaded by destruction of the peritubular sheath.
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Registered trials
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