Evidence map›Paper›PMID 28799254›Full record

ReviewExperimental physiology2017

Sex-specific factors regulating pressure and flow.

Jill N Barnes

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Experimental physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04586049 (Autonomic Dysfunction, Brain Blood Flow and Cognitive Decline in Veterans With Gulf War Illness), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04586049 active not recruitingnot on this mapstarted 2023, after this paper: background citation

Autonomic Dysfunction, Brain Blood Flow and Cognitive Decline in Veterans With Gulf War Illness

TypeobservationalSponsorUniversity of Wisconsin, MadisonRan2023 to 2026Enrolled70ConditionsBrain Blood Flow, Neurovascular ControlArmsMRI, Transcranial Doppler Ultrasound, Sympathetic Nerve Activity
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Uncovering a Sex-Specific cAMP Landscape in Vascular Smooth Muscle.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Static autoregulation in humans.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Review
  13. Article
  14. Review
  15. Article
  16. Sex modifies the relationship between age and neurovascular coupling in healthy adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  17. Article
  18. Article
  19. Trans-cerebral HCOJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jill N BarnesBruno Balke Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0001-6317-4153
University of Wisconsin–Madison · US

Funding

Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's DiseaseU54AG044170 · NIA · MAYO CLINIC ROCHESTER · PI MIELKE, MICHELLE M · 2018 to 2022
$7.7M
Sex-specific Risk for Vascular Dysfunction and Cognitive DeclineP50AG044170 · NIA · MAYO CLINIC ROCHESTER · PI MILLER, VIRGINIA M · 2012 to 2017
$6.1M
Cerebral blood flow, connectivity and cognition: the effect of age and exerciseR00HL118154 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BARNES, JILL NICOLE · 2015 to 2017
$735k
Cerebral blood flow, connectivity and cognition: the effect of age and exerciseK99HL118154 · NHLBI · MAYO CLINIC ROCHESTER · PI BARNES, JILL NICOLE · 2014 to 2015
$180k
NHLBI NIH HHS K99 HL118154NHLBI NIH HHS R00 HL118154NIA NIH HHS P50 AG044170NIA NIH HHS U54 AG044170
6 · The paper itself

Abstract

NEW

findingsWhat is the topic of this review? There are sex- and sex-hormone-specific differences in autonomic control of blood pressure, central haemodynamics and cerebral blood flow. What advances does it highlight? Sex differences in autonomic control of blood pressure may underlie other sex-specific characteristics associated with cerebral blood flow, which can, in turn, affect tissue function. Over the last decade, there have been many published reports on sex differences in blood pressure regulation between young men and young women. The autonomic nervous system is a primary contributor to both acute and long-term blood pressure regulation. Sex differences in blood pressure regulation are likely to have effects that extend beyond mean arterial pressure and that can affect blood flow and tissue function. This short review includes recent literature from our laboratory focusing on autonomic control of the circulation, specifically age- and sex-hormone-related differences in central haemodynamics and cerebral blood flow, and discusses potential clinical implications.

Indexed as

Blood PressureCerebrovascular CirculationAge FactorsAnimalsAutonomic Nervous SystemBaroreflexBlood Flow VelocityBrainCardiovascular SystemFemaleGonadal Steroid HormonesHomeostasisHumansHypertensionMaleMuscle, Smooth, VascularGonadal Steroid Hormonesautonomic nervous systemblood pressurecerebral blood flowmenopausesympathetic nerve activity

Identifiers

PMID28799254
PMCPMC5665704
OpenAlexW2742303581

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.