SynthesisInternational journal of colorectal disease2017
Risk factors for complicated diverticulitis: systematic review and meta-analysis.
Synthesis in International journal of colorectal disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 73 citations in OpenAlex.
- A prospective, randomized, double-blind, placebo-controlled trial of the Kampo formula daiobotanpito combined with antibiotic therapy for acute diverticulitis.Scientific reports · 2025Trial
- Antibiotic Resistance Pattern and Surgical Outcome in Complicated Intra-Abdominal Infections Due to Colorectal Perforation.Antibiotics (Basel, Switzerland) · 2026Article
- A rare case report of pyogenic hepatic abscess secondary to sigmoid diverticulitis.SAGE open medical case reports · 2026Article
- Review
- Surveillance and follow-up in acute diverticulitis with pericolic free gas (ADiFas II): an age-specific analysis.Updates in surgery · 2025Article
- The role of inflammatory parameters in predicting acute complicated diverticulitis.Biomarkers in medicine · 2025Article
- Parameters of Body Composition Predict Clinical Course in Acute Colonic Diverticulitis.Journal of cachexia, sarcopenia and muscle · 2025Article
- Article
- A novel scoring system for predicting disease severity without CT imaging in acute diverticulitis.International journal of colorectal disease · 2024Article
- Free perforation during the first episode of acute diverticulitis: can it be avoided?Updates in surgery · 2024Article
- Hoarseness due to subcutaneous emphysema: a rare presentation of diverticular perforation.Journal of surgical case reports · 2024Article
- The role of infectious parameters in the early prediction of complicated colonic diverticulitis.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2024Article
- Sex, Race, and Ethnicity Differences in Patients Presenting With Diverticular Disease at Emergency Departments in the United States: A National Cross-Sectional Study.Gastro hep advances · 2024Review
- Article
- Metastatic Hepatocellular Carcinoma Masquerading as Acute Diverticulitis.ACG case reports journal · 2022Article
- Current Aspects on the Management of Perforated Acute Diverticulitis: A Narrative Review.Cureus · 2022Review
- Acute Diverticulitis in Young Patients: A Review of the Changing Epidemiology and Etiology.Digestive diseases and sciences · 2022Review
- Frequency of Bowel Movements and Risk of Diverticulitis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022Article
- Machine Learning Model for Outcome Prediction of Patients Suffering from Acute Diverticulitis Arriving at the Emergency Department-A Proof of Concept Study.Diagnostics (Basel, Switzerland) · 2021Article
- Excessive Body Weight and Diverticular Disease.Visceral medicine · 2021Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this systematic review is to identify risk factors that can predict complicated diverticulitis. Uncomplicated diverticulitis is a self-limiting and mild disease, but 10% of patients with diverticulitis develop complications requiring further treatment. It is important to estimate the risk of developing complicated diverticulitis at an early stage to set the right treatment at initial presentation.
methodsEmbase, MEDLINE, and Cochrane databases were searched for studies reporting on risk factors for complicated diverticulitis. Complicated diverticulitis was defined as Hinchey ≥Ib or severe diverticulitis according to the Ambrosetti criteria. Meta-analyses were performed when at least four studies reported on the outcome of interest. This study was conducted according to the PRISMA guidelines.
resultsA total of 12 studies were included with a total of 4619 patients. Most were of reasonable quality. Only the risk factors "age" and "sex" were eligible for meta-analysis, but none showed a significant effect on the risk for complicated diverticulitis. There was reasonable quality of evidence suggesting that high C-reactive protein; white blood cell count; clinical signs including generalized abdominal pain, constipation and vomiting; steroid usage; a primary episode; and comorbidity are risk factors for complicated diverticulitis.
conclusionAlthough high-level evidence is lacking, this study identified several risk factors associated with complicated diverticulitis. Individually, these risk factors have little value in predicting the course of diverticulitis. The authors propose a prognostic model combining these risk factors which might be the next step to aid the physician in predicting the course of diverticulitis and setting the right treatment at initial presentation.
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