Evidence map›Paper›PMID 28798979›Full record

ArticleCancer immunology, immunotherapy : CII2017

Mucosa-associated invariant T cells infiltrate hepatic metastases in patients with colorectal carcinoma but are rendered dysfunctional within and adjacent to tumor microenvironment.

Christopher R Shaler, Mauro E Tun-Abraham, Anton I Skaro, Khashayarsha Khazaie, Alexandra J Corbett, Tina Mele, Roberto Hernandez-Alejandro, S M Mansour Haeryfar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 66 citations in OpenAlex.

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  19. Mouse models illuminate MAIT cell biology.Molecular immunology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Christopher R ShalerDepartment of Microbiology and Immunology, Western University, 1151 Richmond Street, London, ON, N6A 5C1, Canada.
Mauro E Tun-AbrahamDepartment of Surgery, Western University, London, ON, N6A 4V2, Canada.
Anton I SkaroDepartment of Surgery, Western University, London, ON, N6A 4V2, Canada.
Khashayarsha KhazaieDepartment of Immunology, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA.
Alexandra J CorbettDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, 3010, Australia.
Tina MeleDepartment of Surgery, Western University, London, ON, N6A 4V2, Canada.
Roberto Hernandez-AlejandroDepartment of Surgery, Western University, London, ON, N6A 4V2, Canada.
S M Mansour HaeryfarDepartment of Microbiology and Immunology, Western University, 1151 Richmond Street, London, ON, N6A 5C1, Canada. Mansour.Haeryfar@schulich.uwo.ca.ORCID http://orcid.org/0000-0002-1125-8176
Western University · CAMayo Clinic · USThe University of Melbourne · AU

Funding

Proinflammatory T Regulatory Cells in Colon CancerR01CA160436 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KHAZAIE, KHASHAYARSHA · 2012 to 2017
$2.0M
NCI NIH HHS R01 CA160436
6 · The paper itself

Abstract

Mucosa-associated invariant T (MAIT) cells are innate-like T lymphocytes that are unusually abundant in the human liver, a common site of colorectal carcinoma (CRC) metastasis. However, whether they contribute to immune surveillance against colorectal liver metastasis (CRLM) is essentially unexplored. In addition, whether MAIT cell functions can be impacted by chemotherapy is unclear. These are important questions given MAIT cells' potent immunomodulatory and inflammatory properties. Herein, we examined the frequencies and functions of peripheral blood, healthy liver tissue, tumor-margin and tumor-infiltrating MAIT cells in 21 CRLM patients who received no chemotherapy, FOLFOX, or a combination of FOLFOX and Avastin before they underwent liver resection. We found that MAIT cells, defined as CD3ε

Indexed as

AdultAgedAged, 80 and overColorectal NeoplasmsFemaleHumansImmunity, MucosalLiver NeoplasmsMaleMiddle AgedMucosal-Associated Invariant T CellsNeoplasm MetastasisTumor MicroenvironmentChemotherapyColon cancerImmune surveillanceLiver metastasisMAIT cellsTumor-infiltrating lymphocytes

Identifiers

PMID28798979
PMCPMC11029177
OpenAlexW2743368247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.