Evidence map›Paper›PMID 28798962›Full record

ArticleScience advances2017

Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase.

Célia Deville, Marta Carroni, Kamila B Franke, Maya Topf, Bernd Bukau, Axel Mogk, Helen R Saibil

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 133 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Hsp90, DnaK, and ClpB collaborate in protein reactivation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. TheeLife · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway.bioRxiv : the preprint server for biology · 2023
    Article
  17. Review
  18. Temperature Matters: Bacterial Response to Temperature Change.Journal of microbiology (Seoul, Korea) · 2023
    Review
  19. Review
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Célia DevilleDepartment of Crystallography, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.ORCID 0000-0002-0235-6735
Marta CarroniDepartment of Crystallography, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.ORCID 0000-0002-7697-6427
Kamila B FrankeCenter for Molecular Biology of the Heidelberg University, German Cancer Research Center, Heidelberg, Germany.
Maya TopfDepartment of Crystallography, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.ORCID 0000-0002-8185-1215
Bernd BukauCenter for Molecular Biology of the Heidelberg University, German Cancer Research Center, Heidelberg, Germany.
Axel MogkCenter for Molecular Biology of the Heidelberg University, German Cancer Research Center, Heidelberg, Germany.ORCID 0000-0003-3674-5410
Helen R SaibilDepartment of Crystallography, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.ORCID 0000-0002-2266-8891
Institute of Structural and Molecular Biology · GBGerman Cancer Research Center · DE

Funding

Biotechnology and Biological Sciences Research Council BB/L014211/1Medical Research Council G0600084Medical Research Council MR/M019292/1Wellcome Trust
6 · The paper itself

Abstract

Refolding aggregated proteins is essential in combating cellular proteotoxic stress. Together with Hsp70, Hsp100 chaperones, including

Indexed as

Cryoelectron MicroscopyHeat-Shock ProteinsModels, MolecularPromoter Regions, GeneticProtein AggregatesProtein BindingProtein ConformationProtein Interaction Domains and MotifsProtein RefoldingStructure-Activity RelationshipSubstrate SpecificityHeat-Shock ProteinsProtein Aggregates

Identifiers

PMID28798962
PMCPMC5544394
OpenAlexW2744996671

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.