ArticleVirus evolution2017
A novel viral lineage distantly related to herpesviruses discovered within fish genome sequence data.
Article in Virus evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Deep mining reveals the diversity of endogenous viral elements in vertebrate genomes.Nature microbiology · 2024Article
- Integrase-associated niche differentiation of endogenous large DNA viruses in crustaceans.Microbiology spectrum · 2024Article
- A New Sturgeon Herpesvirus from Juvenile Lake SturgeonPathogens (Basel, Switzerland) · 2023Article
- Discovery of novel papillomaviruses in the critically endangered Malayan and Chinese pangolins.Biology letters · 2023Article
- Review
- Novel Virus Identification through Metagenomics: A Systematic Review.Life (Basel, Switzerland) · 2022Review
- Review
- Evolutionary Analysis of Placental Orthologues Reveals Two Ancient DNA Virus Integrations.Journal of virology · 2022Article
- Phylogenomics of the Maverick Virus-Like Mobile Genetic Elements of Vertebrates.Molecular biology and evolution · 2021Article
- Molecular fossils reveal ancient associations of dsDNA viruses with several phyla of fungi.Virus evolution · 2020Article
- Virus-Host Coevolution with a Focus on Animal and Human DNA Viruses.Journal of molecular evolution · 2020Review
- Giant Transposons in Eukaryotes: Is Bigger Better?Genome biology and evolution · 2019Review
- Brief Report: Low Rates of Herpesvirus Detection in Blood of Individuals with Autism Spectrum Disorder and Controls.Journal of autism and developmental disorders · 2019Article
- RNA viruses in trypanosomatid parasites: a historical overview.Memorias do Instituto Oswaldo Cruz · 2018Review
- Fusion ofZoological letters · 2018Article
- Using bioinformatic and phylogenetic approaches to classify transposable elements and understand their complex evolutionary histories.Mobile DNA · 2017Review
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2 authors.
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Abstract
Pathogenic viruses represent a small fraction of viral diversity, and emerging diseases are frequently the result of cross-species transmissions. Therefore, we need to develop high-throughput techniques to investigate a broader range of viral biodiversity across a greater number of species. This is especially important in the context of new practices in agriculture that have arisen to tackle the challenges of global food security, including the rising number of marine and freshwater species that are used in aquaculture. In this study, we demonstrate the utility of combining evolutionary approaches with bioinformatics to mine non-viral genome data for viruses, by adapting methods from paleovirology. We report the discovery of a new lineage of dsDNA viruses that are associated with at least fifteen different species of fish. This approach also enabled us to simultaneously identify sequences that likely represent endogenous viral elements, which we experimentally confirmed in commercial salmon samples. Moreover, genomic analysis revealed that the endogenous sequences have co-opted PiggyBac-like transposable elements, possibly as a mechanism of intragenomic proliferation. The identification of novel viruses from genome data shows that our approach has applications in genomics, virology, and the development of best practices for aquaculture and farming.
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