Evidence map›Paper›PMID 28798682›Full record

ArticleFrontiers in aging neuroscience2017

A Novel Virtual Reality-Based Training Protocol for the Enhancement of the "Mental Frame Syncing" in Individuals with Alzheimer's Disease: A Development-of-Concept Trial.

Silvia Serino, Elisa Pedroli, Cosimo Tuena, Gianluca De Leo, Marco Stramba-Badiale, Karine Goulene, Noemi G Mariotti, Giuseppe Riva

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Article in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  10. Cognitive training for people with mild to moderate dementia.The Cochrane database of systematic reviews · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Silvia SerinoDepartment of Psychology, Università Cattolica del Sacro CuoreMilan, Italy.
Elisa PedroliIRCCS Istituto Auxologico Italiano, Applied Technology for Neuro-Psychology LabMilan, Italy.
Cosimo TuenaDepartment of Psychology, Università Cattolica del Sacro CuoreMilan, Italy.
Gianluca De LeoDepartment of Clinical and Digital Health Sciences, College of Allied Health Sciences, Augusta UniversityAugusta, GA, United States.
Marco Stramba-BadialeDepartment of Geriatrics and Cardiovascular Medicine, IRCCS Istituto Auxologico ItalianoMilan, Italy.
Karine GouleneDepartment of Geriatrics and Cardiovascular Medicine, IRCCS Istituto Auxologico ItalianoMilan, Italy.
Noemi G MariottiIRCCS Istituto Auxologico Italiano, Applied Technology for Neuro-Psychology LabMilan, Italy.
Giuseppe RivaDepartment of Psychology, Università Cattolica del Sacro CuoreMilan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A growing body of evidence suggests that people with Alzheimer's Disease (AD) show compromised spatial abilities. In addition, there exists from the earliest stages of AD a specific impairment in "mental frame syncing," which is the ability to synchronize an allocentric viewpoint-independent representation (including object-to-object information) with an egocentric one by computing the bearing of each relevant "object" in the environment in relation to the stored heading in space (i.e., information about our viewpoint contained in the allocentric viewpoint-dependent representation). The main objective of this development-of-concept trial was to evaluate the efficacy of a novel VR-based training protocol focused on the enhancement of the "mental frame syncing" of the different spatial representations in subjects with AD. We recruited 20 individuals with AD who were randomly assigned to either "VR-based training" or "Control Group." Moreover, eight cognitively healthy elderly individuals were recruited to participate in the VR-based training in order to have a different comparison group. Based on a neuropsychological assessment, our results indicated a significant improvement in long-term spatial memory after the VR-based training for patients with AD; this means that transference of improvements from the VR-based training to more general aspects of spatial cognition was observed. Interestingly, there was also a significant effect of VR-based training on executive functioning for cognitively healthy elderly individuals. In sum, VR could be considered as an advanced embodied tool suitable for treating spatial recall impairments.

Indexed as

allocentricAlzheimer's Diseaseegocentricspatial memoryvirtual reality

Identifiers

PMID28798682
PMCPMC5529401

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.