ArticleScientific reports2017
Analysis of Factors Influencing Diagnostic Accuracy of T-SPOT.TB for Active Tuberculosis in Clinical Practice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Smear-positive Pulmonary Tuberculosis with False-negative Loop-mediated Isothermal Amplification and T-SPOT.TB Assays.Internal medicine (Tokyo, Japan) · 2026Article
- Diagnostic utility of quantitative interferon-gamma release assays in elderly patients with tuberculosis.Microbiology spectrum · 2026Article
- A case report of secondary retroperitoneal lymph node tuberculosis following chemotherapy for acute myeloid leukemia with literature review.Frontiers in oncology · 2026Article
- Transforming tuberculosis diagnosis with clinical metagenomics: progress and roadblocks.Journal of clinical microbiology · 2025Review
- Unveiling the crucial genomic players in pulmonary tuberculosis-associated ferroptosis through bioinformatics scrutiny.BMC infectious diseases · 2025Article
- The clinical value of metagenomic next-generation sequencing in the diagnosis of pulmonary tuberculosis and the exploration of lung microbiota characteristics.Scientific reports · 2025Article
- Systemic vasculitis with latent tuberculosis infection and associated factors: a cross-sectional multicenter study.Clinical rheumatology · 2025Article
- Tuberculosis Diagnosis: Current, Ongoing, and Future Approaches.Diseases (Basel, Switzerland) · 2024Review
- Diagnostic accuracy ofFrontiers in immunology · 2024Article
- Platelets correlate with false negative T-SPOT.TB results by inhibiting interferon-γ production in T cellsFrontiers in cellular and infection microbiology · 2022Article
- Utility of interferon gamma/tumor necrosis factor alpha FluoroSpot assay in differentiation between active tuberculosis and latent tuberculosis infection: a pilot study.BMC infectious diseases · 2021Article
- Role of interferon gamma release assay in the diagnosis and management ofBMJ open ophthalmology · 2021Review
- Clinical evaluation of the T-SPOT.TB test for detection of tuberculosis infection in northeastern Guangdong Province, China.The Journal of international medical research · 2020Article
- Clinical effect of T-SPOT.TB test for the diagnosis of tuberculosis.BMC infectious diseases · 2019Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T-SPOT.TB didn't perform a perfect diagnosis for active tuberculosis (ATB), and some factors may influence the results. We did this study to evaluate possible factors associated with the sensitivity and specificity of T-SPOT.TB, and the diagnostic parameters under varied conditions. Patients with suspected ATB were enrolled prospectively. Influencing factors of the sensitivity and specificity of T-SPOT.TB were evaluated using logistic regression models. Sensitivity, specificity, predictive values (PV), and likelihood ratios (LR) were calculated with consideration of relevant factors. Of the 865 participants, 205 (23.7%) had ATB, including 58 (28.3%) microbiologically confirmed TB and 147 (71.7%) clinically diagnosed TB. 615 (71.7%) were non-TB. 45 (5.2%) cases were clinically indeterminate and excluded from the final analysis. In multivariate analysis, serous effusion was the only independent risk factor related to lower sensitivity (OR = 0.39, 95% CI: 0.18-0.81) among patients with ATB. Among non-TB patients, age, TB history, immunosuppressive agents/glucocorticoid treatment and lymphocyte count were the independent risk factors related to specificity of T-SPOT.TB. Sensitivity, specificity, PV+, PV-, LR+ and LR- of T-SPOT.TB for diagnosis of ATB were 78.5%, 74.1%, 50.3%, 91.2%, 3.0 and 0.3, respectively. This study suggests that influencing factors of sensitivity and specificity of T-SPOT.TB should be considered for interpretation of T-SPOT.TB results.
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