ArticleScientific reports2017
Morphology, membrane nanostructure and stiffness for quality assessment of packed red blood cells.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The resurgence of whole blood transfusion: Evaluating microcirculatory evidence in hemorrhagic trauma care: A review.Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis · 2026Review
- Iron deficiency anemia perturbs erythrocyte morphology and may promote eryptosis.International journal of hematology · 2026Article
- Comparing Nanomechanical Properties and Membrane Roughness Along the Aging of Human Erythrocytes.Methods and protocols · 2025Article
- Modulation of Antioxidant Enzyme Expression of In Vitro Culture-Derived Reticulocytes.Antioxidants (Basel, Switzerland) · 2024Article
- Hypoxically stored RBC resuscitation in a rat model of traumatic brain injury and severe hemorrhagic shock.Life sciences · 2024Article
- Atomic Force Microscopy and High-Resolution Spectrophotometry for Study of Anoxemia and Normoxemia in Model Experiment In Vitro.International journal of molecular sciences · 2023Article
- Label-free testing strategy to evaluate packed red blood cell quality before transfusion to leukemia patients.Scientific reports · 2022Article
- Investigation of Red Blood Cells by Atomic Force Microscopy.Sensors (Basel, Switzerland) · 2022Article
- Topological Relationships Cytoskeleton-Membrane Nanosurface-Morphology as a Basic Mechanism of Total Disorders of RBC Structures.International journal of molecular sciences · 2022Article
- Biomechanical properties of native and cultured red blood cells-Interplay of shape, structure and biomechanics.Frontiers in physiology · 2022Article
- The Toxic Influence of Excess Free Iron on Red Blood Cells in the Biophysical Experiment: An In Vitro Study.Journal of toxicology · 2022Article
- Spatial organization of protein aggregates on red blood cells as physical biomarkers of Alzheimer's disease pathology.Science advances · 2021Article
- Two-step process of cytoskeletal structural damage during long-term storage of packed red blood cells.Blood transfusion = Trasfusione del sangue · 2021Article
- Blood bank storage of red blood cells increases RBC cytoplasmic membrane order and bending rigidity.PloS one · 2021Article
- Nanoscale Changes on RBC Membrane Induced by Storage and Ionizing Radiation: A Mini-Review.Frontiers in physiology · 2021Review
- Deformability of Stored Red Blood Cells.Frontiers in physiology · 2021Review
- Conformational Distortions of the Red Blood Cell Spectrin Matrix Nanostructure in Response to Temperature ChangesScanning · 2019Article
- Red blood cell storage lesion: causes and potential clinical consequences.Blood transfusion = Trasfusione del sangue · 2019Review
- Quantitative phase imaging of erythrocytes under microfluidic constriction in a high refractive index medium reveals water content changes.Microsystems & nanoengineering · 2019Article
- Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy.International journal of molecular sciences · 2018Article
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Authors and funding
6 authors.
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Abstract
Transfusion of packed red blood cells (PRBC) to patients in critical states is often accompanied by post-transfusion complications. This may be related with disturbance of properties of PRBC and their membranes during long-term storage in the hemopreservative solution. The purpose of our work is the study of transformation of morphology, membranes stiffness and nanostructure for assessment of PRBC quality, in vitro. By atomic force microscopy we studied the transformation of cell morphology, the appearance of topological nanodefects of membranes and by atomic force spectroscopy studied the change of membrane stiffness during 40 days of storage of PRBC. It was shown that there is a transition period (20-26 days), in which we observed an increase in the Young's modulus of the membranes 1.6-2 times and transition of cells into irreversible forms. This process was preceded by the appearance of topological nanodefects of membranes. These parameters can be used for quality assessment of PRBC and for improvement of transfusion rules.
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