Evidence map›Paper›PMID 28798251›Full record

ReviewAmerican journal of physiology. Lung cellular and molecular physiology2017

LungMAP: The Molecular Atlas of Lung Development Program.

Maryanne E Ardini-Poleske, Robert F Clark, Charles Ansong, James P Carson, Richard A Corley, Gail H Deutsch, James S Hagood, Naftali Kaminski, Thomas J Mariani, Steven S Potter and 6 more

Abstract readReview
In one paragraph

Review in American journal of physiology. Lung cellular and molecular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

137 citing papers in PubMed.

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77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Maryanne E Ardini-PoleskeRTI International, Research Triangle Park, North Carolina.
Robert F ClarkRTI International, Research Triangle Park, North Carolina; rclark@rti.org.
Charles AnsongPacific Northwest National Laboratory, Richland, Washington.
James P CarsonTexas Advanced Computing Center, Austin, Texas.
Richard A CorleyPacific Northwest National Laboratory, Richland, Washington.
Gail H DeutschUniversity of Washington, Seattle, Washington.
James S HagoodUniversity of California, San Diego, California.
Naftali KaminskiYale School of Medicine, New Haven, Connecticut.
Thomas J MarianiUniversity of Rochester Medical Center, Rochester, New York.
Steven S PotterCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Gloria S PryhuberUniversity of Rochester Medical Center, Rochester, New York.
David WarburtonChildren's Hospital of Los Angeles, Los Angeles, California.
Jeffrey A WhitsettCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Scott M PalmerDuke University School of Medicine, Durham, North Carolina; and.
Namasivayam AmbalavananUniversity of Alabama, Birmingham, Alabama.
LungMAP Consortium

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
The University of Rochester's Clinical and Translational Science InstituteUL1TR002001 · NCATS · UNIVERSITY OF ROCHESTER · PI WILSON, KAREN M., ZAND, MARTIN S · 2016 to 2024
$34.6M
The University of Rochester's Clinical and Translational Science InstituteUL1TR000042 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$14.4M
BioRepository for INvestigation of Diseases of the Lung (BRINDL) - Phase IIIU01HL148861 · NHLBI · UNIVERSITY OF ROCHESTER · PI GLORIA S PRYHUBER · 2019 to 2026
$9.7M
Editing Alveolar Progenitor Cells for Correction of Monogenic DiseaseU01HL134745 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KOTTON, DARRELL N., MORRISEY, EDWARD E · 2016 to 2022
$8.3M
Molecular Atlas of Lung Development - Data Coordinating CenterU01HL122638 · NHLBI · DUKE UNIVERSITY · PI CLARK, ROBERT F, PALMER, SCOTT M · 2014 to 2018
$7.5M
Biorepository for Investigation of Neonatal Diseases of Lung-Normal (BRINDL-NL)U01HL122700 · NHLBI · UNIVERSITY OF ROCHESTER · PI PRYHUBER, GLORIA S · 2014 to 2018
$6.1M
Transcriptional Programming of Asthma Related Pathology in Respiratory EpitheliaR01HL095580 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WHITSETT, JEFFREY A · 2009 to 2017
$4.7M
Center for Lung Development Imaging and OmicsU01HL122703 · NHLBI · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI ANSONG, CHARLES K, CARSON, JAMES PAUL · 2014 to 2018
$4.5M
Molecular anatomy of human alveolar developmentU01HL122681 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WARBURTON, DAVID · 2014 to 2018
$4.0M
"Lung MAP" Atlas Research CenterU01HL122642 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI POTTER, S. STEVEN, WHITSETT, JEFFREY A · 2014 to 2018
$3.9M
Alveolar DevMAPU01HL122626 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMBALAVANAN, NAMASIVAYAM, HAGOOD, JAMES S. · 2014 to 2018
$3.7M
NCATS NIH HHS UL1 TR000042NCATS NIH HHS UL1 TR002001NCI NIH HHS P30 CA013148NHLBI NIH HHS R01 HL095580NHLBI NIH HHS R01 HL136722NHLBI NIH HHS U01 HL122626NHLBI NIH HHS U01 HL122638NHLBI NIH HHS U01 HL122642NHLBI NIH HHS U01 HL122681NHLBI NIH HHS U01 HL122700NHLBI NIH HHS U01 HL122703NHLBI NIH HHS U01 HL134745NHLBI NIH HHS U01 HL148861
6 · The paper itself

Abstract

The National Heart, Lung, and Blood Institute is funding an effort to create a molecular atlas of the developing lung (LungMAP) to serve as a research resource and public education tool. The lung is a complex organ with lengthy development time driven by interactive gene networks and dynamic cross talk among multiple cell types to control and coordinate lineage specification, cell proliferation, differentiation, migration, morphogenesis, and injury repair. A better understanding of the processes that regulate lung development, particularly alveologenesis, will have a significant impact on survival rates for premature infants born with incomplete lung development and will facilitate lung injury repair and regeneration in adults. A consortium of four research centers, a data coordinating center, and a human tissue repository provides high-quality molecular data of developing human and mouse lungs. LungMAP includes mouse and human data for cross correlation of developmental processes across species. LungMAP is generating foundational data and analysis, creating a web portal for presentation of results and public sharing of data sets, establishing a repository of young human lung tissues obtained through organ donor organizations, and developing a comprehensive lung ontology that incorporates the latest findings of the consortium. The LungMAP website (www.lungmap.net) currently contains more than 6,000 high-resolution lung images and transcriptomic, proteomic, and lipidomic human and mouse data and provides scientific information to stimulate interest in research careers for young audiences. This paper presents a brief description of research conducted by the consortium, database, and portal development and upcoming features that will enhance the LungMAP experience for a community of users.

Indexed as

Databases, GeneticProteomicsAnimalsGene Regulatory NetworksHumansLungOrganogenesisRegeneration3D imaginglung developmentlung imaginglung omicssingle cell analysisweb resource

Identifiers

PMID28798251
PMCPMC5792185

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.