ArticleArteriosclerosis, thrombosis, and vascular biology2017
Characterization of Macrophage Polarization States Using Combined Measurement of 2-Deoxyglucose and Glutamine Accumulation: Implications for Imaging of Atherosclerosis.
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Article in Arteriosclerosis, thrombosis, and vascular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
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39 citing papers in PubMed, 59 citations in OpenAlex.
- Application of glutamine metabolism-related gene signatures in the non-invasive diagnosis of coronary artery disease: integrating bulk and single-cell transcriptomics.Journal of bioenergetics and biomembranes · 2026Article
- Single-cell RNA sequencing reveals that host Glutamine Metabolism Inhibition Enhances Macrophage Phagocytosis ofbioRxiv : the preprint server for biology · 2026Article
- Single-cell to pre-clinical evaluation of Trem2, Folr2, and Slc7a7 as macrophage-associated biomarkers for atherosclerosis.Cardiovascular research · 2025Article
- STK11 coordinates IL-4 signaling with metabolic reprogramming to control M2 macrophage polarization and antitumor immunity.Science advances · 2025Article
- Slc7a7 licenses macrophage glutaminolysis for restorative functions in atherosclerosis.Nature metabolism · 2025Article
- Improving cardiovascular risk stratification: the role of abdominal obesity in predicting MACEs.Cardiovascular diabetology · 2025Article
- Mediator complex: update of key insights into transcriptional regulation of ancestral framework and its role in cardiovascular diseases.European journal of medical research · 2025Review
- Dichotomous roles of IL-36 and IL-38 in cardiovascular disease.Frontiers in immunology · 2025Review
- Review
- Phytol from3 Biotech · 2024Article
- Cardiac Metabolism.Advances in experimental medicine and biology · 2024Review
- Macrophage Polarization and Osteoclast Differentiation.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Crosstalk between synovial macrophages and fibroblasts in rheumatoid arthritis.Histology and histopathology · 2023Review
- Modulation of LPS-Induced Neurodegeneration by Intestinal Helminth Infection in Ageing Mice.International journal of molecular sciences · 2023Article
- Diabetic vascular diseases: molecular mechanisms and therapeutic strategies.Signal transduction and targeted therapy · 2023Review
- Dealing with Macrophage Plasticity to Address Therapeutic Challenges in Head and Neck Cancers.International journal of molecular sciences · 2022Article
- Divergence of acetate uptake in proinflammatory and inflammation-resolving macrophages: implications for imaging atherosclerosis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Survey of Approaches for Investigation of Atherosclerosis In Vivo.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2Frontiers in immunology · 2022Article
- Modulation of Macrophage Immunometabolism: A New Approach to Fight Infections.Frontiers in immunology · 2022Review
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Authors and funding
10 authors at 1 institution in 1 country.
Sina TavakoliFrom the Department of Radiology (S.T.) and Department of Medicine (S.T.), University of Pittsburgh, PA; Department of Cellular and Structural Biology (K.D), Department of Pharmacology (J.D.S.), Department of Biochemistry (H.N.N., R.A.), Department of Clinical Laboratory Sciences (Y.L., R.A.), Department of Radiology (P.A.J., B.G., R.A.), and Research Imaging Institute (P.A.J.), University of Texas Health Science Center at San Antonio; and Section of Cardiovascular Medicine (J.T., M.M.S.) and Cardiovascular Research Center (J.T., M.M.S.), Yale School of Medicine, New Haven, CT.
Kevin DownsFrom the Department of Radiology (S.T.) and Department of Medicine (S.T.), University of Pittsburgh, PA; Department of Cellular and Structural Biology (K.D), Department of Pharmacology (J.D.S.), Department of Biochemistry (H.N.N., R.A.), Department of Clinical Laboratory Sciences (Y.L., R.A.), Department of Radiology (P.A.J., B.G., R.A.), and Research Imaging Institute (P.A.J.), University of Texas Health Science Center at San Antonio; and Section of Cardiovascular Medicine (J.T., M.M.S.) and Cardiovascular Research Center (J.T., M.M.S.), Yale School of Medicine, New Haven, CT.
John D ShortFrom the Department of Radiology (S.T.) and Department of Medicine (S.T.), University of Pittsburgh, PA; Department of Cellular and Structural Biology (K.D), Department of Pharmacology (J.D.S.), Department of Biochemistry (H.N.N., R.A.), Department of Clinical Laboratory Sciences (Y.L., R.A.), Department of Radiology (P.A.J., B.G., R.A.), and Research Imaging Institute (P.A.J.), University of Texas Health Science Center at San Antonio; and Section of Cardiovascular Medicine (J.T., M.M.S.) and Cardiovascular Research Center (J.T., M.M.S.), Yale School of Medicine, New Haven, CT.
Huynh Nga NguyenFrom the Department of Radiology (S.T.) and Department of Medicine (S.T.), University of Pittsburgh, PA; Department of Cellular and Structural Biology (K.D), Department of Pharmacology (J.D.S.), Department of Biochemistry (H.N.N., R.A.), Department of Clinical Laboratory Sciences (Y.L., R.A.), Department of Radiology (P.A.J., B.G., R.A.), and Research Imaging Institute (P.A.J.), University of Texas Health Science Center at San Antonio; and Section of Cardiovascular Medicine (J.T., M.M.S.) and Cardiovascular Research Center (J.T., M.M.S.), Yale School of Medicine, New Haven, CT.
Yanlai LaiFrom the Department of Radiology (S.T.) and Department of Medicine (S.T.), University of Pittsburgh, PA; Department of Cellular and Structural Biology (K.D), Department of Pharmacology (J.D.S.), Department of Biochemistry (H.N.N., R.A.), Department of Clinical Laboratory Sciences (Y.L., R.A.), Department of Radiology (P.A.J., B.G., R.A.), and Research Imaging Institute (P.A.J.), University of Texas Health Science Center at San Antonio; and Section of Cardiovascular Medicine (J.T., M.M.S.) and Cardiovascular Research Center (J.T., M.M.S.), Yale School of Medicine, New Haven, CT.
Paul A JerabekFrom the Department of Radiology (S.T.) and Department of Medicine (S.T.), University of Pittsburgh, PA; Department of Cellular and Structural Biology (K.D), Department of Pharmacology (J.D.S.), Department of Biochemistry (H.N.N., R.A.), Department of Clinical Laboratory Sciences (Y.L., R.A.), Department of Radiology (P.A.J., B.G., R.A.), and Research Imaging Institute (P.A.J.), University of Texas Health Science Center at San Antonio; and Section of Cardiovascular Medicine (J.T., M.M.S.) and Cardiovascular Research Center (J.T., M.M.S.), Yale School of Medicine, New Haven, CT.
Beth GoinsFrom the Department of Radiology (S.T.) and Department of Medicine (S.T.), University of Pittsburgh, PA; Department of Cellular and Structural Biology (K.D), Department of Pharmacology (J.D.S.), Department of Biochemistry (H.N.N., R.A.), Department of Clinical Laboratory Sciences (Y.L., R.A.), Department of Radiology (P.A.J., B.G., R.A.), and Research Imaging Institute (P.A.J.), University of Texas Health Science Center at San Antonio; and Section of Cardiovascular Medicine (J.T., M.M.S.) and Cardiovascular Research Center (J.T., M.M.S.), Yale School of Medicine, New Haven, CT.
Jakub ToczekFrom the Department of Radiology (S.T.) and Department of Medicine (S.T.), University of Pittsburgh, PA; Department of Cellular and Structural Biology (K.D), Department of Pharmacology (J.D.S.), Department of Biochemistry (H.N.N., R.A.), Department of Clinical Laboratory Sciences (Y.L., R.A.), Department of Radiology (P.A.J., B.G., R.A.), and Research Imaging Institute (P.A.J.), University of Texas Health Science Center at San Antonio; and Section of Cardiovascular Medicine (J.T., M.M.S.) and Cardiovascular Research Center (J.T., M.M.S.), Yale School of Medicine, New Haven, CT.
Mehran M SadeghiFrom the Department of Radiology (S.T.) and Department of Medicine (S.T.), University of Pittsburgh, PA; Department of Cellular and Structural Biology (K.D), Department of Pharmacology (J.D.S.), Department of Biochemistry (H.N.N., R.A.), Department of Clinical Laboratory Sciences (Y.L., R.A.), Department of Radiology (P.A.J., B.G., R.A.), and Research Imaging Institute (P.A.J.), University of Texas Health Science Center at San Antonio; and Section of Cardiovascular Medicine (J.T., M.M.S.) and Cardiovascular Research Center (J.T., M.M.S.), Yale School of Medicine, New Haven, CT.
Reto AsmisFrom the Department of Radiology (S.T.) and Department of Medicine (S.T.), University of Pittsburgh, PA; Department of Cellular and Structural Biology (K.D), Department of Pharmacology (J.D.S.), Department of Biochemistry (H.N.N., R.A.), Department of Clinical Laboratory Sciences (Y.L., R.A.), Department of Radiology (P.A.J., B.G., R.A.), and Research Imaging Institute (P.A.J.), University of Texas Health Science Center at San Antonio; and Section of Cardiovascular Medicine (J.T., M.M.S.) and Cardiovascular Research Center (J.T., M.M.S.), Yale School of Medicine, New Haven, CT. asmis@uthscsa.edu.
University of Pittsburgh · US
Funding
Nox4 and the Redox-Regulation of MKPs in Monocyte Recruitment and AtherosclerosisR01HL115858 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ASMIS, RETO H.R. · 2012 to 2015
$1.6MNHLBI NIH HHS R01 HL115858
Abstract
objectiveDespite the early promising results of APPROACH AND
resultsMurine peritoneal macrophages (MΦ) were activated ex vivo into proinflammatory states with either lipopolysaccharide (MΦ
conclusionsCombined assessment of glutamine and 2-deoxyglucose accumulation improves the ex vivo identification of macrophage activation states. Combined ex vivo metabolic imaging demonstrates heterogenous and distinct patterns of substrate accumulation in atherosclerotic lesions. Further studies are required to define the in vivo significance of glutamine uptake in atherosclerosis and its potential application in identification of vulnerable plaques.
Indexed as
Fluorodeoxyglucose F18Positron-Emission TomographyAnimalsAortaAtherosclerosisAutoradiographyDeoxyglucoseGlutamineMacrophagesMicePlaque, AtheroscleroticDeoxyglucoseFluorodeoxyglucose F18Glutamineanimalsenergy metabolismglucoseinflammationmice
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