ArticleArteriosclerosis, thrombosis, and vascular biology2017
The Hemoglobin Homolog Cytoglobin in Smooth Muscle Inhibits Apoptosis and Regulates Vascular Remodeling.
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Article in Arteriosclerosis, thrombosis, and vascular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
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22 citing papers in PubMed, 30 citations in OpenAlex.
- Smooth Muscle Cell Cytoglobin is a Negative Regulator of Atherosclerotic Fibrous Cap Development.bioRxiv : the preprint server for biology · 2026Article
- Genetic deletion of cytoglobin exacerbates cardiac hypertrophy and inhibits cardiac fibroblast activation independent of changes in blood pressure.bioRxiv : the preprint server for biology · 2026Article
- FAPNature communications · 2025Article
- Electronic cigarette vape decreases nitric oxide bioavailability in vascular smooth muscle cells via increased cytoglobin-mediated metabolism.Free radical biology & medicine · 2025Article
- Regulation of DNA damage and transcriptional output in the vasculature through a cytoglobin-HMGB2 axis.Redox biology · 2023Article
- Identification and quantification of protein nitration sites in human coronary artery smooth muscle cells in the absence and presence of peroxynitrous acid/peroxynitrite.Redox biology · 2023Article
- Ordered Motions in the Nitric-Oxide Dioxygenase Mechanism of Flavohemoglobin and Assorted Globins with Tightly Coupled Reductases.Advances in experimental medicine and biology · 2023Article
- The role of globins in cardiovascular physiology.Physiological reviews · 2022Review
- Role of cytoglobin in cigarette smoke constituent-induced loss of nitric oxide bioavailability in vascular smooth muscle cells.Nitric oxide : biology and chemistry · 2022Article
- Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin.Scientific reports · 2021Article
- Redox sensor properties of human cytoglobin allosterically regulate heme pocket reactivity.Free radical biology & medicine · 2021Article
- Lessons from the post-genomic era: Globin diversity beyond oxygen binding and transport.Redox biology · 2020Review
- Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases.International journal of molecular sciences · 2020Review
- Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis.Clinical and molecular hepatology · 2020Review
- Regulation of Nitric Oxide Metabolism and Vascular Tone by Cytoglobin.Antioxidants & redox signaling · 2020Review
- Emerging perspectives on cytoglobin, beyond NO dioxygenase and peroxidase.Redox biology · 2020Review
- Vascular smooth muscle-MAPK14 is required for neointimal hyperplasia by suppressing VSMC differentiation and inducing proliferation and inflammation.Redox biology · 2019Article
- Endothelial cell-induced cytoglobin expression in vascular smooth muscle cells contributes to modulation of nitric oxide.Vascular pharmacology · 2018Article
- Transcriptome Sequencing Reveals the Differentially Expressed lncRNAs and mRNAs Involved in Cryoinjuries in Frozen-Thawed Giant Panda (International journal of molecular sciences · 2018Article
- Reporting Sex and Sex Differences in Preclinical Studies.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
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Authors and funding
19 authors at 2 institutions in 1 country.
Frances L Jourd'heuilFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
Haiyan XuFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
Timothy ReillyFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
Keneta McKellarFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
Chaymae El AlaouiFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
Julia SteppichFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
Yong Feng LiuFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
Wen ZhaoFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
Roman GinnanFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
David ContiFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
Reynold Lopez-SolerFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
Arif AsifFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
Rebecca K KellerFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
John J SchwarzFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
Le Thi Thanh ThuyFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
Norifumi KawadaFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
Xiaochun LongFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
Harold A SingerFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.).
David Jourd'heuilFrom the Department of Molecular and Cellular Physiology (F.L.J., H.X., T.R., K.M., C.E.A., J.S., Y.F.L., W.Z., R.G., R.K.K., J.J.S., X.L., H.A.S., D.J.) and Surgery Transplantation (D.C., R.L.-S.), Albany Medical Center, NY; Seton Hall-Hackensack Meridian School of Medicine, Jersey Shore University Medical Center, Hackensack-Meridian Health, Neptune, NJ (A.A.); and Department of Hepatology, Graduate School of Medicine, Osaka City University, Japan (L.T.T.T., N.K.). jourdhd@mail.amc.edu.
Hackensack Meridian Health · USJersey Shore University Medical Center · US
Funding
CALCIUM/CALMODULIN ACTIVATED KINIASES IN SMOOTH MUSCLER01HL049426 · NHLBI · WEIS CENTER FOR RESEARCH-GEISINGER CLINC · PI SINGER, HAROLD A · 1994 to 2019
$6.2MNovel Role of MAPK14 in Regulation of VSMC Contractile PhenotypeR01HL122686 · NHLBI · AUGUSTA UNIVERSITY · PI LONG, XIAOCHUN · 2014 to 2022
$4.0MNHLBI NIH HHS R01 HL049426NHLBI NIH HHS R01 HL122686
Abstract
objectiveThe role of hemoglobin and myoglobin in the cardiovascular system is well established, yet other globins in this context are poorly characterized. Here, we examined the expression and function of cytoglobin (CYGB) during vascular injury. APPROACH AND
resultsWe characterized CYGB content in intact vessels and primary vascular smooth muscle (VSM) cells and used 2 different vascular injury models to examine the functional significance of CYGB in vivo. We found that CYGB was strongly expressed in medial arterial VSM and human veins. In vitro and in vivo studies indicated that CYGB was lost after VSM cell dedifferentiation. In the rat balloon angioplasty model, site-targeted delivery of adenovirus encoding shRNA specific for CYGB prevented its reexpression and decreased neointima formation. Similarly, 4 weeks after complete ligation of the left common carotid,
conclusionsThese results indicate that CYGB is expressed in vessels primarily in differentiated medial VSM cells where it regulates neointima formation and inhibits apoptosis after injury.
Indexed as
ApoptosisAnimalsCaspase 3Cell DifferentiationCytoglobinDown-RegulationEnzyme ActivationGlobinsMiceMice, KnockoutMuscle, Smooth, VascularNeointimaNitric Oxide Synthase Type IIOxidation-ReductionRatsVascular RemodelingCaspase 3CYGB protein, humanCygb protein, mouseCygb protein, ratCytoglobinGlobinsNitric Oxide Synthase Type IIangioplastyapoptosisarteriovenous fistulamyoglobinnitric oxide
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