Evidence map›Paper›PMID 28798131›Full record

ArticleScience (New York, N.Y.)2017

Pavlovian conditioning-induced hallucinations result from overweighting of perceptual priors.

A R Powers, C Mathys, P R Corlett

Registry-linked trialAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04210557 (Models of Auditory Hallucination), which is not on this map. Cited by 356 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
356citing papers in PubMed, 5 pooled it
36.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04210557 naterminatednot on this mapstarted 2020, after this paper: background citation

Models of Auditory Hallucination

TypeinterventionalSponsorYale UniversityRan2020 to 2021Enrolled1ConditionsSchizophrenia, Schizo Affective Disorder, Auditory HallucinationArmsTranscranial Magnetic Stimulation (TMS)
3 · Its place in the literature

Who cites it

356 citing papers in PubMed, 5 syntheses or guidelines pooled it, 727 citations in OpenAlex.

  1. Pooled it
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  5. Meta-analysis of human prediction error for incentives, perception, cognition, and action.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Pooled it
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  11. Overview of the DREADDs chemogenetics and the patent landscape of their actuators.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
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  20. The dysconnection hypothesis of schizophrenia: a 30-year update.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
    Article

296 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 4 countries.

A R PowersDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3057-5043
C MathysInternational School for Advanced Studies (SISSA), Trieste, Italy.ORCID 0000-0003-4079-5453
P R CorlettDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. philip.corlett@yale.edu.ORCID 0000-0002-5368-1992
Yale University · USScuola Internazionale Superiore di Studi Avanzati · IT

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
Clinical Neuroscience Research Training Program in PsychiatryT32MH019961 · NIMH · YALE UNIVERSITY · PI Christopher John Pittenger · 1996 to 2026
$5.9M
Schizophrenia Research FellowshipR25MH071584 · NIMH · YALE UNIVERSITY · PI Christopher John Pittenger · 2005 to 2026
$4.4M
Pathophysiology of Auditory HallucinationsR01MH067073 · NIMH · YALE UNIVERSITY · PI CORLETT, PHILIP · 2003 to 2015
$3.0M
NCATS NIH HHS UL1 TR000142NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH067073NIMH NIH HHS R25 MH071584NIMH NIH HHS T32 MH019961
6 · The paper itself

Abstract

Some people hear voices that others do not, but only some of those people seek treatment. Using a Pavlovian learning task, we induced conditioned hallucinations in four groups of people who differed orthogonally in their voice-hearing and treatment-seeking statuses. People who hear voices were significantly more susceptible to the effect. Using functional neuroimaging and computational modeling of perception, we identified processes that differentiated voice-hearers from non-voice-hearers and treatment-seekers from non-treatment-seekers and characterized a brain circuit that mediated the conditioned hallucinations. These data demonstrate the profound and sometimes pathological impact of top-down cognitive processes on perception and may represent an objective means to discern people with a need for treatment from those without.

Indexed as

Conditioning, ClassicalPerceptionAcoustic StimulationAdultBrainComputer SimulationFemaleHallucinationsHearingHumansMaleModels, NeurologicalNerve NetNeuroimagingPhotic StimulationPsychotic Disorders

Identifiers

PMID28798131
PMCPMC5802347
OpenAlexW2744535290

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.