ArticleScience (New York, N.Y.)2017
Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion.
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 718 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
718citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
718 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of Probiotic Supplementation on Core Symptoms of Autism Spectrum Disorder in Children.Nutrients · 2026Pooled it
- Dietary fibre blend improves gut health in patients with irritable bowel syndrome following a low FODMAP diet: a randomised, double-blind control trial.European journal of nutrition · 2026Trial
- Gut microbiota responses to bariatric surgery are associated with metabolic outcomes and type 2 diabetes remission.Nature metabolism · 2026Trial
- Feeding microbes to feed the Gut: inulin reprograms intestinal epithelial metabolism and proliferation through HIF1α.Gut microbes · 2026Review
- Sulfide dynamics at the gut-microbiota interface: diet, oxygen and redox interplay.Gut microbes · 2026Review
- The gut microbiota as a regulator of intestinal stem-cell fate: bacterial and fungal control of differentiation and regeneration.Gut microbes · 2026Review
- Spatial mapping of human colonic niches reveals rapid, mucus-specific microbiota disruption after bowel cleansing.Gut microbes · 2026Article
- Branched-chain amino acids and gut microbiota: coregulation and impact on neurological function via the gut-brain axis.Gut microbes · 2026Review
- Gut microbiota and diet in colorectal cancer: Converging determinants of carcinogenesis.Gut microbes · 2026Review
- Gut microbiota translocation and dissemination in health: can it be beneficial and purposeful?Gut microbes · 2026Review
- Microbial metabolite-driven mechanisms linking the gut microbiome to atherosclerosis: multi-omic and translational perspectives.Gut microbes · 2026Review
- Metabolite 4-hydroxybenzoic acid, modulated by cigarette smoke exposure, functions as a protective factor in dextran sodium sulfate-induced colitis.Journal of gastroenterology · 2026Article
- Gut microbiome shifts in chronic systolic heart failure are associated with disease severity and clinical improvement.Nature cardiovascular research · 2026Article
- Oral uracil treatment increases susceptibility to rectal SIV infection.PLoS pathogens · 2026Article
- Microbiome ecology and antibiotic treatment failure: resistance spread, microbial competition and community engineering.Microbial genomics · 2026Review
- Gut Microbiota-Mucosal Immune Interactions Underlying Intestinal Homeostasis in Weaned Piglets.Animals : an open access journal from MDPI · 2026Review
- Immunotherapy restores therapeutic efficacy of fecal microbiome transplants to treatbioRxiv : the preprint server for biology · 2026Article
- Review
- Regulation of Inducible Nitric Oxide Synthase (NOS2) Expression in Healthy and Inflamed Bowel: A Narrative Review.International journal of molecular sciences · 2026Review
- Integrated metabolomic and gut microbiota analyses reveal TCA cycle dysfunction in broiler skeletal disorders and the protective effect of L‑malic acid.Journal of animal science and biotechnology · 2026Article
658 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors.
Mariana X ByndlossDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-2122-4156
Erin E OlsanDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-5650-1133
Fabian Rivera-ChávezDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.
Connor R TiffanyDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.
Stephanie A CevallosDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-7091-1577
Kristen L LokkenDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-2058-2015
Teresa P TorresDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0003-2316-4705
Austin J ByndlossDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-4810-8585
Franziska FaberDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-8700-6522
Yandong GaoDepartment of Biomedical Engineering, College of Engineering, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-4761-6035
Yael LitvakDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-0183-2816
Christopher A LopezDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0001-7880-0460
Gege XuDepartment of Chemistry, College of Letters and Sciences, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-0792-2636
Eleonora NapoliDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.
Cecilia GiuliviDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.
Renée M TsolisDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0001-9131-6657
Alexander RevzinDepartment of Biomedical Engineering, College of Engineering, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-8737-3250
Carlito B LebrillaDepartment of Chemistry, College of Letters and Sciences, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0001-7190-5323
Andreas J BäumlerDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA. ajbaumler@ucdavis.edu.ORCID 0000-0001-9152-7809
Funding
UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3MExacerbation of colitis by the microbiotaR01AI112445 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Andreas J Baumler · 2015 to 2026
$6.2MMicrobiota Outgrowth by SalmonellaR01AI096528 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAUMLER, ANDREAS J · 2011 to 2025
$6.1MUniversity of Michigan Postbaccalaureate Research Education Program (UM PREP)R25GM086262 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN · 2009 to 2024
$6.1MMechanism of Colonization ResistanceR01AI112949 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Andreas J Baumler · 2016 to 2026
$5.2MUC Davis CTSC TL1 Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility MentorshipTL1TR001861 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MEDICI, VALENTINA · 2016 to 2025
$4.7MInnate immune sensing of ER stress during bacterial infectionR01AI109799 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TSOLIS, RENEE M · 2014 to 2024
$3.6MAnimal Models of Infectious Diseases Training ProgramT32AI060555 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI MCSORLEY, STEPHEN J · 2004 to 2025
$3.3MSurgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondriaRC1DK087307 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GIULIVI, CECILIA, HAVEL, PETER J · 2009 to 2010
$985kInflammation-derived sugars lower resistance against SalmonellaR21AI114922 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAUMLER, ANDREAS J · 2015 to 2016
$430kMechanism of E. coli colonization resistanceR56AI112949 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAUMLER, ANDREAS J · 2014 to 2014
$382kDetection of bacterial Type IV secretion by the unfolded protein responseR21AI112258 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TSOLIS, RENEE M · 2014 to 2015
$350kNCATS NIH HHS TL1 TR001861NCATS NIH HHS UL1 TR001860NIAID NIH HHS F31 AI112241NIAID NIH HHS R01 AI096528NIAID NIH HHS R01 AI109799NIAID NIH HHS R01 AI112445NIAID NIH HHS R01 AI112949NIAID NIH HHS R21 AI112258NIAID NIH HHS R21 AI114922NIAID NIH HHS R56 AI112949NIAID NIH HHS T32 AI060555NIDDK NIH HHS RC1 DK087307NIGMS NIH HHS R25 GM086262
Abstract
Perturbation of the gut-associated microbial community may underlie many human illnesses, but the mechanisms that maintain homeostasis are poorly understood. We found that the depletion of butyrate-producing microbes by antibiotic treatment reduced epithelial signaling through the intracellular butyrate sensor peroxisome proliferator-activated receptor γ (PPAR-γ). Nitrate levels increased in the colonic lumen because epithelial expression of
Indexed as
Gastrointestinal MicrobiomeAngiopoietin-Like Protein 4AnilidesAnimalsAnti-Bacterial AgentsButyratesCaco-2 CellsClostridiumColitisColonDysbiosisEnterobacteriaceaeEpithelial CellsFemaleGene ExpressionHomeostasis2-chloro-5-nitrobenzanilideAngiopoietin-Like Protein 4AnilidesAnti-Bacterial AgentsButyratesNitratesNitric Oxide Synthase Type IIPPAR gammaStreptomycin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.