ArticleScience (New York, N.Y.)2017
Eye patches: Protein assembly of index-gradient squid lenses.
Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Comparative analysis of the structure and crystallin composition of the lenses of freshwater fish and gastropods with respect to their vision.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Liquid-liquid phase separation driven by charge heterogeneity.Communications physics · 2024Article
- Design and Characterization of Model Systems that Promote and Disrupt Transparency of Vertebrate Crystallins In Vitro.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Protein Association in Solution: Statistical Mechanical Modeling.Biomolecules · 2023Review
- The effect of fibre cell remodelling on the power and optical quality of the lens.Journal of the Royal Society, Interface · 2023Article
- Topological Considerations in Biomolecular Condensation.Biomolecules · 2023Review
- An Introduction to the Stickers-and-Spacers Framework as Applied to Biomolecular Condensates.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Genomes of Two Flying Squid Species Provide Novel Insights into Adaptations of Cephalopods to Pelagic Life.Genomics, proteomics & bioinformatics · 2022Article
- Manipulating polydispersity of lens β-crystallins using divalent cations demonstrates evidence of calcium regulation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens.The Journal of biological chemistry · 2022Review
- Genome and transcriptome mechanisms driving cephalopod evolution.Nature communications · 2022Article
- Spatially uniform dynamics in equilibrium colloidal gels.Science advances · 2021Article
- Nanocrystalline protein domains via salting-out.Acta crystallographica. Section F, Structural biology communications · 2021Article
- Higher-order organization of biomolecular condensates.Open biology · 2021Review
- The intracellular environment affects protein-protein interactions.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Imbalances in the eye lens proteome are linked to cataract formation.Nature structural & molecular biology · 2021Article
- 3D printed gradient index glass optics.Science advances · 2020Article
- Evolution and development of complex eyes: a celebration of diversity.Development (Cambridge, England) · 2020Review
- Designer protein assemblies with tunable phase diagrams in living cells.Nature chemical biology · 2020Article
- SASBDB: Towards an automatically curated and validated repository for biological scattering data.Protein science : a publication of the Protein Society · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A parabolic relationship between lens radius and refractive index allows spherical lenses to avoid spherical aberration. We show that in squid, patchy colloidal physics resulted from an evolutionary radiation of globular S-crystallin proteins. Small-angle x-ray scattering experiments on lens tissue show colloidal gels of S-crystallins at all radial positions. Sparse lens materials form via low-valence linkages between disordered loops protruding from the protein surface. The loops are polydisperse and bind via a set of hydrogen bonds between disordered side chains. Peripheral lens regions with low particle valence form stable, volume-spanning gels at low density, whereas central regions with higher average valence gel at higher densities. The proteins demonstrate an evolved set of linkers for self-assembly of nanoparticles into volumetric materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.