ArticleProceedings of the National Academy of Sciences of the United States of America2017
Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
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Who cites it
101 citing papers in PubMed, 136 citations in OpenAlex.
- Decoding the origins of cellular self-organization for engineered biology.Nature biotechnology · 2026Review
- In vitro and in vivo models for androgenetic alopecia drug development.Disease models & mechanisms · 2026Review
- Hesperidin from Chenpi Ameliorates Skin Photoaging by Targeting HSPA1L to Stabilize GPX4 and Suppress Ferroptosis.Antioxidants (Basel, Switzerland) · 2026Article
- Metabolic adaptation drives self-organization during skin organoid morphogenesis.Nature communications · 2026Article
- Matrix-free cryo-microneedles array patch for 3D hair follicle organoids delivery and rapid hair regeneration.Materials today. Bio · 2026Article
- Evolutionary insights into a skin fold.Nature · 2026Article
- Toward system-level integration of organoids for regenerative medicine.Burns & trauma · 2026Review
- Hypoxia and metabolic adaptation drive self-organization in organoid morphogenesis and tissue regeneration.Burns & trauma · 2026Article
- HmmrResearch (Washington, D.C.) · 2026Article
- A Bioengineered Skin Organoid Platform for Modeling Human Skin Physiology and Cytotoxicity.Research square · 2025Article
- Targeted protein degradation of Wnt/β-catenin signaling pathway: an effective strategy for cancer therapy.Journal of translational medicine · 2025Review
- Immunosenescence and organoids: pathophysiology and therapeutic opportunities.Immunity & ageing : I & A · 2025Review
- Advances in sweat gland organoids: construction, molecular mechanisms, and challenges.Stem cell research & therapy · 2025Review
- Synergizing biomaterials and cellular molecular pathways: a new frontier in hair follicle generation.Journal of translational medicine · 2025Review
- Embryonic Avian Skin Explant Cultures: A Versatile Model for Investigating Tissue Patterning Mechanisms.The Journal of investigative dermatology · 2025Review
- Spatiotemporal Adaptations-Driven Dynamic Thra Activation Simulates a Skin Wound Healing Response.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Wnt10b Regulation of Hair Follicle Development, Regeneration, and Skin Diseases.Stem cell reviews and reports · 2025Review
- Causes and therapeutic limitations of clinical alopecia and the advent of human pluripotent stem cell follicular transplantation.Stem cell research & therapy · 2025Review
- Organizational principles of integumentary organs: Maximizing variations for effective adaptation.Developmental biology · 2025Review
41 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 4 institutions in 5 countries.
Funding
Abstract
Organoids made from dissociated progenitor cells undergo tissue-like organization. This in vitro self-organization process is not identical to embryonic organ formation, but it achieves a similar phenotype in vivo. This implies genetic codes do not specify morphology directly; instead, complex tissue architectures may be achieved through several intermediate layers of cross talk between genetic information and biophysical processes. Here we use newborn and adult skin organoids for analyses. Dissociated cells from newborn mouse skin form hair primordia-bearing organoids that grow hairs robustly in vivo after transplantation to nude mice. Detailed time-lapse imaging of 3D cultures revealed unexpected morphological transitions between six distinct phases: dissociated cells, cell aggregates, polarized cysts, cyst coalescence, planar skin, and hair-bearing skin. Transcriptome profiling reveals the sequential expression of adhesion molecules, growth factors, Wnts, and matrix metalloproteinases (MMPs). Functional perturbations at different times discern their roles in regulating the switch from one phase to another. In contrast, adult cells form small aggregates, but then development stalls in vitro. Comparative transcriptome analyses suggest suppressing epidermal differentiation in adult cells is critical. These results inspire a strategy that can restore morphological transitions and rescue the hair-forming ability of adult organoids: (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.