Evidence map›Paper›PMID 28797570›Full record

SynthesisEuropean urology2017

Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma.

Mitchell J Machiela, Jonathan N Hofmann, Robert Carreras-Torres, Kevin M Brown, Mattias Johansson, Zhaoming Wang, Matthieu Foll, Peng Li, Nathaniel Rothman, Sharon A Savage and 102 more

Erratum issuedOpen access · bronzeAbstract readMeta-AnalysisMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European urology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Review
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  7. Review
  8. Article
  9. Review
  10. Article
  11. Role of telomere length in human carcinogenesis (Review).International journal of oncology · 2023
    Review
  12. Review
  13. Article
  14. Article
  15. Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
  16. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

112 authors at 20 institutions in 18 countries.

Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Jonathan N HofmannDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Robert Carreras-TorresInternational Agency for Research on Cancer (IARC), Lyon, France.
Kevin M BrownDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Mattias JohanssonInternational Agency for Research on Cancer (IARC), Lyon, France.
Zhaoming WangSt. Jude Children's Research Hospital, Memphis, TN, USA.
Matthieu FollInternational Agency for Research on Cancer (IARC), Lyon, France.
Peng LiInternational Agency for Research on Cancer (IARC), Lyon, France.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Sharon A SavageDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Valerie GaborieauInternational Agency for Research on Cancer (IARC), Lyon, France.
James D McKayInternational Agency for Research on Cancer (IARC), Lyon, France.
Yuanqing YeDepartment of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Marc HenrionIcahn School of Medicine, New York, NY, USA.
Fiona BruinsmaCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Australia.
Susan JordanQIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; School of Public Health, The University of Queensland, Brisbane, Australia.
Gianluca SeveriCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, Australia; Human Genetics Foundation (HuGeF), Torino, Italy; Centre de Recherche en Épidémiologie et Santé des Populations, Université Paris-Saclay, UPS, USQ, Gustave Roussy, Villejuif, France.
Kristian HveemHUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Sweden.
Lars J VattenDepartment of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Tony FletcherLondon School of Hygiene and Tropical Medicine, University of London, London, UK.
Kvetoslava KoppovaRegional Authority of Public Health in Banska Bystrica, Banska Bystrica, Slovakia.
Susanna C LarssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Rosamonde E BanksLeeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital, Leeds, UK.
Peter J SelbyLeeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital, Leeds, UK.
Douglas F EastonDepartment of Oncology, and Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Paul PharoahDepartment of Oncology, and Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Gabriella AndreottiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Laura E Beane FreemanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Stella KoutrosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Satu MannistoNational Institute for Health and Welfare, Helsinki, Finland.
Stephanie WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Peter E ClarkVanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Todd E EdwardsVanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Loren LipworthVanderbilt-Ingram Cancer Center, Nashville, TN, USA.
Susan M GapsturAmerican Cancer Society, Atlanta, GA, USA.
Victoria L StevensAmerican Cancer Society, Atlanta, GA, USA.
Hallie CarolDana-Farber Cancer Institute, Boston, MA, USA.
Matthew L FreedmanDana-Farber Cancer Institute, Boston, MA, USA.
Mark M PomerantzDana-Farber Cancer Institute, Boston, MA, USA.
Eunyoung ChoBrown University, Providence, RI, USA.
Peter KraftHarvard T.H. Chan School of Public Health, Boston, MA, USA.
Mark A PrestonBrigham and Women's Hospital, Boston, MA, USA.
Kathryn M WilsonHarvard T.H. Chan School of Public Health, Boston, MA, USA.
J Michael GazianoBrigham and Women's Hospital, Boston, MA, USA; Veterans Administration, Boston, MA, USA.
Howard S SessoHarvard T.H. Chan School of Public Health, Boston, MA, USA.
Amanda BlackDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Wen-Yi HuangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
John G AnemaDivision of Urology, Spectrum Health, Grand Rapids, MI, USA.
Richard J KahnoskiDivision of Urology, Spectrum Health, Grand Rapids, MI, USA.
Brian R LaneDivision of Urology, Spectrum Health, Grand Rapids, MI, USA; College of Human Medicine, Michigan State University, Grand Rapids, MI, USA.
Sabrina L NoyesVan Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, MI, USA.
David PetilloVan Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, MI, USA.
Leandro M ColliDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Joshua N SampsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Celine BesseCentre National de Recherche en Genomique Humaine (CNRGH), Institut de biologie François Jacob, Commissariat à l'Energie Atomique et aux Energies Alternatives, Evry, France.
Helene BlancheFondation Jean Dausset-Centre d'Etude du Polymorphisme Humain, Paris, France.
Anne BolandCentre National de Recherche en Genomique Humaine (CNRGH), Institut de biologie François Jacob, Commissariat à l'Energie Atomique et aux Energies Alternatives, Evry, France.
Laurie BurdetteDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Egor ProkhortchoukCenter 'Bioengineering' of the Russian Academy of Sciences, Moscow, Russian Federation; Kurchatov Scientific Center, Moscow, Russian Federation.
Konstantin G SkryabinCenter 'Bioengineering' of the Russian Academy of Sciences, Moscow, Russian Federation; Kurchatov Scientific Center, Moscow, Russian Federation.
Meredith YeagerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Mirjana MijuskovicClinic for Nephrology, Military Medical Academy, Belgrade, Serbia.
Miodrag OgnjanovicInternational Organization for Cancer Prevention and Research (IOCPR), Belgrade, Serbia.
Lenka ForetovaInternational Organization for Cancer Prevention and Research (IOCPR), Belgrade, Serbia.
Ivana HolcatovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Vladimir JanoutSecond Faculty of Medicine, Institute of Public Health and Preventive Medicine, Charles University, Prague, Czech Republic.
Dana MatesDepartment of Preventive Medicine, Faculty of Medicine, Palacky University, Czech Republic.
Anush MukeriyaNational Institute of Public Health, Bucharest, Romania.
Stefan RascuRussian N.N. Blokhin Cancer Research Centre, Moscow, Russian Federation.
David ZaridzeNational Institute of Public Health, Bucharest, Romania.
Vladimir BenckoCarol Davila University of Medicine and Pharmacy, Th. Burghele Hospital, Bucharest, Romania.
Cezary CybulskiFirst Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University, Prague, Czech Republic.
Eleonora FabianovaRegional Authority of Public Health in Banska Bystrica, Banska Bystrica, Slovakia.
Viorel JingaCarol Davila University of Medicine and Pharmacy, Th. Burghele Hospital, Bucharest, Romania.
Jolanta LissowskaThe M Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland.
Jan LubinskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Marie NavratilovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Peter RudnaiNational Public Health Center, National Directorate of Environmental Health, Budapest, Hungary.
Neonila Szeszenia-DabrowskaDepartment of Epidemiology, Institute of Occupational Medicine, Lodz, Poland.
Simone BenhamouINSERM U946, Paris, France; CNRS UMR8200, Institute Gustave Roussy, Villejuif, France.
Geraldine Cancel-TassinCeRePP, Paris, France; UPMC Univ Paris 06, Institut Universitaire de Cancérologie, Paris, France.
Olivier CussenotCeRePP, Paris, France; UPMC Univ Paris 06, Institut Universitaire de Cancérologie, Paris, France; AP-HP, Department of Urology, Hopitaux Universitaires Est Parisien Tenon, Paris, France.
H Bas Bueno-de-MesquitaDepartment for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands; Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London, UK; Department of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Pantai Valley, Kuala Lumpur, Malaysia.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Eric J DuellUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
Börje LjungbergDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.
Raviprakash T SitaramDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.
Ulrike PetersFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Emily WhiteFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Garnet L AndersonFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Lisa JohnsonFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Juhua LuoDepartment of Epidemiology and Biostatistics, School of Public Health Indiana University Bloomington, Bloomington, IN, USA.
Julie BuringHarvard T.H. Chan School of Public Health, Boston, MA, USA.
I-Min LeeHarvard T.H. Chan School of Public Health, Boston, MA, USA; Brigham and Women's Hospital, Boston, MA, USA.
Wong-Ho ChowDepartment of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lee E MooreDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Christopher WoodDepartment of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Timothy EisenUniversity of Cambridge, Cambridge, UK.
James LarkinRoyal Marsden NHS Foundation Trust, London, UK.
Toni K ChoueiriDana-Farber Cancer Institute, Boston, MA, USA.
G Mark LathropMcGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada.
Bin Tean TehVan Andel Research Institute, Center for Cancer Genomics and Quantitative Biology, Grand Rapids, MI, USA.
Jean-Francois DeleuzeCentre National de Recherche en Genomique Humaine (CNRGH), Institut de biologie François Jacob, Commissariat à l'Energie Atomique et aux Energies Alternatives, Evry, France; Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain, Paris, France.
Xifeng WuDepartment of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Richard S HoulstonThe Institute of Cancer Research, London, UK.
Paul BrennanInternational Agency for Research on Cancer (IARC), Lyon, France.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA.
Ghislaine SceloInternational Agency for Research on Cancer (IARC), Lyon, France.
Mark P PurdueDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA. Electronic address: purduem@mail.nih.gov.
National Institutes of Health · USCentre International de Recherche sur le Cancer · FRNational Cancer Institute · USDana-Farber Cancer Institute · USFred Hutch Cancer Center · USHarvard University · USThe University of Texas MD Anderson Cancer Center · USVan Andel Institute · USAmerican Cancer Society · USCancer Council Victoria · AUCarol Davila University of Medicine and Pharmacy · ROKarolinska Institutet · SEMasaryk Memorial Cancer Institute · CZPublic Health Authority of the Slovak Republic · SKSpectrum Health · USUmeå University · SEVanderbilt University · USBrigham and Women's Hospital · USBrown University · USCharles University · CZ

Funding

Cancer Genetic Markers of SusceptibilityZIACP010187 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI CHANOCK, STEPHEN J. · 2009 to 2025
$4.7M
Molecular pathways linking obesity and RCC tumorigenesis (PQ1)R01CA170298 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GU, JIAN · 2012 to 2015
$2.1M
Cancer Research UK 10124Cancer Research UK 16561Cancer Research UK 20265Cancer Research UK 6858Department of Health RP-PG-0707-10101Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA CP010187Medical Research Council MR/K012126/1NCI NIH HHS R01 CA170298NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CWorld Health Organization 001
6 · The paper itself

Abstract

backgroundRelative telomere length in peripheral blood leukocytes has been evaluated as a potential biomarker for renal cell carcinoma (RCC) risk in several studies, with conflicting findings.

objectiveWe performed an analysis of genetic variants associated with leukocyte telomere length to assess the relationship between telomere length and RCC risk using Mendelian randomization, an approach unaffected by biases from temporal variability and reverse causation that might have affected earlier investigations. DESIGN, SETTING, AND

participantsGenotypes from nine telomere length-associated variants for 10 784 cases and 20 406 cancer-free controls from six genome-wide association studies (GWAS) of RCC were aggregated into a weighted genetic risk score (GRS) predictive of leukocyte telomere length. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Odds ratios (ORs) relating the GRS and RCC risk were computed in individual GWAS datasets and combined by meta-analysis. RESULTS AND LIMITATIONS: Longer genetically inferred telomere length was associated with an increased risk of RCC (OR=2.07 per predicted kilobase increase, 95% confidence interval [CI]:=1.70-2.53, p<0.0001). As a sensitivity analysis, we excluded two telomere length variants in linkage disequilibrium (R

conclusionsOur investigation adds to the growing body of evidence indicating some aspect of longer telomere length is important for RCC risk. PATIENT SUMMARY: Telomeres are segments of DNA at chromosome ends that maintain chromosomal stability. Our study investigated the relationship between genetic variants associated with telomere length and renal cell carcinoma risk. We found evidence suggesting individuals with inherited predisposition to longer telomere length are at increased risk of developing renal cell carcinoma.

Indexed as

Polymorphism, Single NucleotideTelomere HomeostasisCarcinoma, Renal CellCase-Control StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansKidney NeoplasmsLeukocytesMendelian Randomization AnalysisOdds RatioPhenotypeRisk AssessmentRisk FactorsTelomereGenetic variantsMendelian randomizationRenal cell carcinomaRiskTelomere length

Identifiers

PMID28797570
PMCPMC5641242
OpenAlexW2744156886

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.