ArticleBMC genomics2017
Characterisation of protein families in spider digestive fluids and their role in extra-oral digestion.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
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- Exploring Spiders Without Venom as New Sources of Peptidase Inhibitors.International journal of molecular sciences · 2025Article
- Digestion in the arachnid Mischonyx squalidus as a probable source of lipids to synthesize opiliones defense and communication molecules.Scientific reports · 2025Article
- Beyond venomous fangs: Uloboridae spiders have lost their venom but not their toxicity.BMC biology · 2025Article
- Comparing Nutrient Intake by Wolf Spiders (Ecology and evolution · 2025Article
- Functionally-Graded Serrated Fangs Allow Spiders to Mechanically Cut Silk, Carbon and Kevlar Fibers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Enlightening the toxinological dark matter of spider venom enzymes.npj biodiversity · 2024Article
- Spider-Venom Peptides: Structure, Bioactivity, Strategy, and Research Applications.Molecules (Basel, Switzerland) · 2023Review
- Variation among arthropod taxa in the amino acid content of exoskeleton and digestible tissue.Ecology and evolution · 2023Article
- Digestive enzymes and sphingomyelinase D in spiders without venom (Uloboridae).Scientific reports · 2023Article
- Spiders' digestive system as a source of trypsin inhibitors: functional activity of a member of atracotoxin structural family.Scientific reports · 2023Article
- Immunostimulation ofPeerJ · 2023Article
- Evolution, Expression Patterns, and Distribution of Novel Ribbon Worm Predatory and Defensive Toxins.Molecular biology and evolution · 2022Article
- The Enzymatic Core of Scorpion Venoms.Toxins · 2022Article
- Structural and evolutionary insights into astacin metallopeptidases.Frontiers in molecular biosciences · 2022Article
- Brazilian Theraphosidae: a toxicological point of view.The journal of venomous animals and toxins including tropical diseases · 2021Review
- Temperature dependency of predation: Increased killing rates and prey mass consumption by predators with warming.Ecology and evolution · 2020Article
- Venomics of the ectoparasitoid wasp Bracon nigricans.BMC genomics · 2020Article
- Assessing the Risks of Topically Applied dsRNA-Based Products to Non-target Arthropods.Frontiers in plant science · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpiders are predaceous arthropods that are capable of subduing and consuming relatively large prey items compared to their own body size. For this purpose, spiders have evolved potent venoms to immobilise prey and digestive fluids that break down nutrients inside the prey's body by means of extra-oral digestion (EOD). Both secretions contain an array of active proteins, and an overlap of some components has been anecdotally reported, but not quantified. We systematically investigated the extent of such protein overlap. As venom injection and EOD succeed each other, we further infer functional explanations, and, by comparing two spider species belonging to different clades, assess its adaptive significance for spider EOD in general.
resultsWe describe the protein composition of the digestive fluids of the mygalomorph Acanthoscurria geniculata and the araneomorph Stegodyphus mimosarum, in comparison with previously published data on a third spider species. We found a number of similar hydrolases being highly abundant in all three species. Among them, members of the family of astacin-like metalloproteases were particularly abundant. While the importance of these proteases in spider venom and digestive fluid was previously noted, we now highlight their widespread use across different spider taxa. Finally, we found species specific differences in the protein overlap between venom and digestive fluid, with the difference being significantly greater in S. mimosarum compared to A. geniculata.
conclusionsThe injection of venom precedes the injection with digestive fluid, and the overlap of proteins between venom and digestive fluid suggests an early involvement in EOD. Species specific differences in the overlap may reflect differences in ecology between our two study species. The protein composition of the digestive fluid of all the three species we compared is highly similar, suggesting that the cocktail of enzymes is highly conserved and adapted to spider EOD.
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