ArticlePloS one2017
Computationally designed lattices with tuned properties for tissue engineering using 3D printing.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling.Advanced healthcare materials · 2026Review
- The size effect on mechanical and permeability properties of porous bone structures fabricated by selective laser melting.Frontiers in bioengineering and biotechnology · 2026Article
- Section on innovative spine research and novel technologies: fusion cage design, materials, and coatings: Science versus hype.North American Spine Society journal · 2025Article
- Computational optimization of 3D printed bone scaffolds using orthogonal array-driven FEA and neural network modeling.Scientific reports · 2025Article
- Bioactive Glass Microscaffolds Fabricated by Two-Photon Lithography.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Computational methods for biofabrication in tissue engineering and regenerative medicine - a literature review.Computational and structural biotechnology journal · 2024Review
- Scalable Hierarchically Structured Materials from a Multiscale Particle System Enabled by Microscaffolds.3D printing and additive manufacturing · 2024Article
- Reasoning on Pore Terminology in 3D Bioprinting.Gels (Basel, Switzerland) · 2024Review
- 3D-Printed Osteoinductive Polymeric Scaffolds with Optimized Architecture to Repair a Sheep Metatarsal Critical-Size Bone Defect.Advanced healthcare materials · 2023Article
- Design and Manufacturing of a Novel Trabecular Tibial Implant.Materials (Basel, Switzerland) · 2023Article
- Metal and Polymer Based Composites Manufactured Using Additive Manufacturing-A Brief Review.Polymers · 2023Review
- Recent advancement in finite element analysis of spinal interbody cages: A review.Frontiers in bioengineering and biotechnology · 2023Review
- Mechanics of 3D-Printed Polymer Lattices with Varied Design and Processing Strategies.Polymers · 2022Article
- Wall Shear Stress Analysis and Optimization in Tissue Engineering TPMS Scaffolds.Materials (Basel, Switzerland) · 2022Article
- Additively manufactured metallic biomaterials.Bioactive materials · 2022Review
- 3D Printing Silk-Based Bioresorbable Piezoelectric Self-Adhesive Holey Structures forACS applied materials & interfaces · 2022Article
- Restoration and Possible Upgrade of a Historical Motorcycle Part Using Powder Bed Fusion.Materials (Basel, Switzerland) · 2022Article
- Challenges in computational fluid dynamics applications for bone tissue engineering.Proceedings. Mathematical, physical, and engineering sciences · 2022Review
- Design Optimization of Lattice Structures under Compression: Study of Unit Cell Types and Cell Arrangements.Materials (Basel, Switzerland) · 2021Article
- Understanding and utilizing textile-based electrostatic flocking for biomedical applications.Applied physics reviews · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue scaffolds provide structural support while facilitating tissue growth, but are challenging to design due to diverse property trade-offs. Here, a computational approach was developed for modeling scaffolds with lattice structures of eight different topologies and assessing properties relevant to bone tissue engineering applications. Evaluated properties include porosity, pore size, surface-volume ratio, elastic modulus, shear modulus, and permeability. Lattice topologies were generated by patterning beam-based unit cells, with design parameters for beam diameter and unit cell length. Finite element simulations were conducted for each topology and quantified how elastic modulus and shear modulus scale with porosity, and how permeability scales with porosity cubed over surface-volume ratio squared. Lattices were compared with controlled properties related to porosity and pore size. Relative comparisons suggest that lattice topology leads to specializations in achievable properties. For instance, Cube topologies tend to have high elastic and low shear moduli while Octet topologies have high shear moduli and surface-volume ratios but low permeability. The developed method was utilized to analyze property trade-offs as beam diameter was altered for a given topology, and used to prototype a 3D printed lattice embedded in an interbody cage for spinal fusion treatments. Findings provide a basis for modeling and understanding relative differences among beam-based lattices designed to facilitate bone tissue growth.
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Registered trials
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