Evidence map›Paper›PMID 28797030›Full record

SynthesisBritish journal of cancer2017

One-step nucleic acid amplification assay is an accurate technique for sentinel lymph node biopsy of breast cancer patients: a meta-analysis.

Fang Shi, Qian Zhang, Zhenzhen Liang, Mengmeng Zhang, Xin Liu

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Frontiers in oncology · 2025
    Article
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  7. Observational
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  13. The new TNM-based staging of breast cancer.Virchows Archiv : an international journal of pathology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Fang ShiDepartment of Epidemiology and Statistics, School of Public Health, Jilin University, No. 1163, Xinmin Avenue, Changchun 130021, China.
Qian ZhangDepartment of Epidemiology and Statistics, School of Public Health, Jilin University, No. 1163, Xinmin Avenue, Changchun 130021, China.
Zhenzhen LiangDepartment of Epidemiology and Statistics, School of Public Health, Jilin University, No. 1163, Xinmin Avenue, Changchun 130021, China.
Mengmeng ZhangDepartment of Epidemiology and Statistics, School of Public Health, Jilin University, No. 1163, Xinmin Avenue, Changchun 130021, China.
Xin LiuDepartment of Epidemiology and Statistics, School of Public Health, Jilin University, No. 1163, Xinmin Avenue, Changchun 130021, China.
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo estimate the accuracy of one-step nucleic acid amplification (OSNA) assay as an intra-operative sentinel lymph node biopsy (SLNB) for sentinel lymph node (SLN) metastasis in breast cancer.

methodsPubMed, Cochrane Library and Web of Science databases were searched by two independent reviewers to retrieve literature with per-patient analysis. The deadline was up until December 2016. A meta-analysis was performed using STATA, Meta-Disc, and Revman software. A random-effects model was used and subgroup analysis was carried out to identify possible sources of heterogeneity.

resultsAccording to the inclusion criteria, 2833 patients from 12 studies were included in this meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) and the area under the sROC curve (AUC) for detecting SLN metastasis were 0.87 (95% CI 0.81-0.91), 0.92 (95% CI 0.86-0.95), 10.65 (95% CI 6.18-18.34), 0.14 (95% CI 0.10-0.20), 75.08 (95% CI 37.77-149.22) and 0.94 (95% CI 0.91-0.95), respectively.

conclusionsThe present study adds the evidence that OSNA assay is an accurate molecular diagnostic tool for intra-operatively detecting SLN metastasis in breast cancer. One-step nucleic acid amplification assay might be introduced into clinical usage for replacing traditional intro-operative diagnostic methods of SLNB.

Indexed as

AxillaBreast NeoplasmsCarcinomaFemaleHumansKeratin-19Lymph Node ExcisionNeoplasm StagingNucleic Acid Amplification TechniquesRNA, MessengerSentinel Lymph NodeSentinel Lymph Node BiopsyKeratin-19RNA, Messenger

Identifiers

PMID28797030
PMCPMC5674095
OpenAlexW2742517652

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.