ArticlePloS one2017
Hypercholesterolemia induced cerebral small vessel disease.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Genotype-phenotype correlations of heterozygous HTRA1-related cerebral small vessel disease: case report and systematic review.Neurogenetics · 2021Pooled it
- Statin Therapy Protects White Matter in Cerebral Small Vessel Disease Independent of Lipid-Lowering: Biomarker and Neuroimaging Evidence.Brain and behavior · 2026Article
- Associations between cerebral blood transit time, amyloid-β pathology and cognitive decline in non-demented older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Dysfunction of Microcirculation in Atherosclerosis: Implications of Nitric Oxide, Oxidative Stress, and Inflammation.International journal of molecular sciences · 2025Review
- The interaction between dysfunction of vasculature and tauopathy in Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Cerebral small vessel disease as a possibly immune-related adverse event of immunotherapy in lung cancer patients: a retrospective study.Frontiers in immunology · 2025Article
- Pathogenesis of Cerebral Small Vessel Disease: Role of the Glymphatic System Dysfunction.International journal of molecular sciences · 2024Review
- A novel rat model of cerebral small vessel disease based on vascular risk factors of hypertension, aging, and cerebral hypoperfusion.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Sex Differences in the Association Between Vascular Risk Factors and Cognitive Decline: A UK Biobank Study.JACC. Advances · 2024Article
- SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study.Cardiovascular diabetology · 2024Article
- Chronic gastritis may predict risk of cerebral small vessel disease.BMC gastroenterology · 2023Article
- Excessive salt intake accelerates the progression of cerebral small vessel disease in older adults.BMC geriatrics · 2023Article
- Impaired Cholesterol Metabolism, Neurons, and Neuropsychiatric Disorders.Experimental neurobiology · 2023Review
- The Preventive Effect of Exercise and Oral Branched-Chain Amino Acid Supplementation on Obesity-Induced Brain Changes in Ldlr-/-.Leiden Mice.Nutrients · 2023Article
- Elevated Lipoprotein-Associated Phospholipase A2 Is Associated With Intracranial Atherosclerosis.Frontiers in neurology · 2022Article
- Distinct peripheral blood monocyte and neutrophil transcriptional programs following intracerebral hemorrhage and different etiologies of ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Plasma lipids are associated with white matter microstructural changes and axonal degeneration.Brain imaging and behavior · 2021Article
- Neurovascular Coupling Is Impaired in Hypertensive and Diabetic Subjects Without Symptomatic Cerebrovascular Disease.Frontiers in aging neuroscience · 2021Article
- Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors.Frontiers in aging neuroscience · 2021Article
- Anticancer and Immunomodulatory Benefits of Taro (International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile hypercholesterolemia plays a causative role for the development of ischemic stroke in large vessels, its significance for cerebral small vessel disease (CSVD) remains unclear. We thus aimed to understand the detailed relationship between hypercholesterolemia and CSVD using the well described Ldlr-/- mouse model.
methodsWe used Ldlr-/- mice (n = 16) and wild-type (WT) mice (n = 15) at the age of 6 and 12 months. Ldlr-/- mice develop high plasma cholesterol levels following a high fat diet. We analyzed cerebral capillaries and arterioles for intravascular erythrocyte accumulations, thrombotic vessel occlusions, blood-brain barrier (BBB) dysfunction and microbleeds.
resultsWe found a significant increase in the number of erythrocyte stases in 6 months old Ldlr-/- mice compared to all other groups (P < 0.05). Ldlr-/- animals aged 12 months showed the highest number of thrombotic occlusions while in WT animals hardly any occlusions could be observed (P < 0.001). Compared to WT mice, Ldlr-/- mice did not display significant gray matter BBB breakdown. Microhemorrhages were observed in one Ldlr-/- mouse that was 6 months old. Results did not differ when considering subcortical and cortical regions.
conclusionsIn Ldlr-/- mice, hypercholesterolemia is related to a thrombotic CSVD phenotype, which is different from hypertension-related CSVD that associates with a hemorrhagic CSVD phenotype. Our data demonstrate a relationship between hypercholesterolemia and the development of CSVD. Ldlr-/- mice appear to be an adequate animal model for research into CSVD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.