Evidence map›Paper›PMID 28796552›Full record

ArticleAJR. American journal of roentgenology2017

Diagnostic Accuracy of MRI Versus CT for the Evaluation of Acute Appendicitis in Children and Young Adults.

Sonja Kinner, Perry J Pickhardt, Erica L Riedesel, Kara G Gill, Jessica B Robbins, Douglas R Kitchin, Timothy J Ziemlewicz, John B Harringa, Scott B Reeder, Michael D Repplinger

Abstract readComparative Study
In one paragraph

Article in AJR. American journal of roentgenology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Magnetic resonance imaging (MRI) for diagnosis of acute appendicitis.The Cochrane database of systematic reviews · 2021
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  19. MR Imaging-based Evaluation of Mesenteric Ischemia Caused by Strangulated Small Bowel Obstruction and Mesenteric Venous Occlusion: An Experimental Study Using Rabbits.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Sonja Kinner1 Department of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53705.
Perry J Pickhardt1 Department of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53705.
Erica L Riedesel1 Department of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53705.
Kara G Gill1 Department of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53705.
Jessica B Robbins1 Department of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53705.
Douglas R Kitchin1 Department of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53705.
Timothy J Ziemlewicz1 Department of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53705.
John B Harringa3 BerbeeWalsh Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI.
Scott B Reeder1 Department of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53705.
Michael D Repplinger1 Department of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53705.
University of Wisconsin–Madison · USEssen University Hospital · DE

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Technical Validation of MRI Biomarkers of Liver FatR01DK088925 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B., SIRLIN, CLAUDE B · 2010 to 2021
$7.1M
Institutional Clinical and Translational Science AwardKL2TR000428 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$6.2M
Evolution of Quantitative MRI Biomarkers of Metabolic Syndrome During PubertyK24DK102595 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2014 to 2018
$927k
Identifying Barriers and Facilitators to the Implementation of Radiation-Free Imaging Protocols in the Emergency DepartmentK08DK111234 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REPPLINGER, MICHAEL DEAN · 2016 to 2018
$488k
NCATS NIH HHS KL2 TR000428NCATS NIH HHS UL1 TR000427NIDDK NIH HHS K08 DK111234NIDDK NIH HHS K24 DK102595NIDDK NIH HHS R01 DK088925
6 · The paper itself

Abstract

objectiveAppendicitis is frequently diagnosed in the emergency department, most commonly using CT. The purpose of this study was to compare the diagnostic accuracy of contrast-enhanced MRI with that of contrast-enhanced CT for the diagnosis of appendicitis in adolescents when interpreted by abdominal radiologists and pediatric radiologists. SUBJECTS AND

methodsOur study included a prospectively enrolled cohort of 48 patients (12-20 years old) with nontraumatic abdominal pain who underwent CT and MRI. Fellowship-trained abdominal and pediatric radiologists reviewed all CT and MRI studies in randomized order, blinded to patient outcome. Likelihood for appendicitis was rated on a 5-point scale (1, definitely not appendicitis; 5, definitely appendicitis) for CT, the unenhanced portion of the MRI, and the entire contrast-enhanced MRI study. ROC curves were generated and AUC compared for each scan type for all six readers and then stratified by radiologist type. Image test characteristics, interrater reliability, and reading times were compared.

resultsSensitivity and specificity were 85.9% (95% CI, 76.2-92.7%) and 93.8% (95% CI, 89.7-96.7%) for unenhanced MRI, 93.6% (95% CI, 85.6-97.9%) and 94.3% (95% CI, 90.2-97%) for contrast-enhanced MRI, and 93.6% (95% CI, 85.6-97.9%) and 94.3% (95% CI, 90.2-97%) for CT. No difference was found in the diagnostic accuracy or interpretation time when comparing abdominal radiologists to pediatric radiologists (CT, 3.0 min vs 2.8 min; contrast-enhanced MRI, 2.4 min vs 1.8 min; unenhanced MRI, 1.5 min vs 2.3 min). Substantial agreement between abdominal and pediatric radiologists was seen for all methods (κ = 0.72-0.83).

conclusionThe diagnostic accuracy of MRI to diagnose appendicitis was very similar to CT. No statistically significant difference in accuracy was observed between imaging modality or radiologist subspecialty.

Indexed as

Magnetic Resonance ImagingTomography, X-Ray ComputedAcute DiseaseAdolescentAppendicitisChildFemaleHumansMaleProspective StudiesRadiography, AbdominalReproducibility of ResultsYoung AdultappendicitisCTMRIpediatric

Identifiers

PMID28796552
PMCPMC5639901
OpenAlexW2744781580

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.